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Rabbit Polyclonal KRT222 Antibody

  • 中文名: KRT222抗体
  • 别    名: KA21; KRT222P
货号: IPDX09059
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesKA21; KRT222P
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是基于角蛋白相关抗体研究的常见主题构造的示例性参考文献(请注意,KRT222可能为虚构或笔误,实际文献需通过学术数据库核实):

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1. **文献名称**: "Characterization of a Novel Anti-KRT222 Antibody for Epithelial Cell Marker Studies"

**作者**: Smith A, et al.

**摘要**: 本研究开发了一种高特异性单克隆抗体(克隆号:K222-3B5),靶向人类角蛋白KRT222.通过免疫组化及Western blot验证,该抗体在正常皮肤组织及鳞状细胞癌中显示特异性染色,提示KRT222可能作为上皮细胞分化或肿瘤进展的生物标志物。

2. **文献名称**: "KRT222 Expression in Corneal Tissue Regeneration"

**作者**: Lee H, et al.

**摘要**: 利用兔抗KRT222多克隆抗体,研究发现KRT222在角膜损伤修复过程中显著上调,可能参与细胞骨架重塑。抗体特异性通过siRNA敲除实验确认,为角膜疾病治疗提供潜在靶点。

3. **文献名称**: "Development and Validation of KRT222 Antibody for Diagnostic Applications"

**作者**: Garcia R, et al.

**摘要**: 文章报道了一种基于KRT222抗体的ELISA检测方法,用于区分良性皮肤病变与恶性黑色素瘤。抗体经流式细胞术验证,显示在转移性癌细胞系中KRT222表达升高,提示其临床诊断潜力。

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**注意事项**:

- 上述文献为示例,实际研究中可能无直接对应KRT222的报道,建议核实目标蛋白名称(如是否为KRT22、KRT2等常见角蛋白变体)。

- 检索真实文献推荐使用PubMed、Web of Science等平台,关键词组合如"KRT22 antibody"或"Keratin 222"。

- 若需具体文献,请提供更准确的蛋白标识或研究背景。

背景信息

The KRT222 antibody is a research tool designed to detect keratin 22 (KRT22), a member of the keratin family of intermediate filament proteins. Keratins are critical for maintaining structural integrity in epithelial cells, contributing to cell adhesion, mechanical stability, and stress resilience. KRT22. specifically encoded by the *KRT22* gene, is classified as a type I keratin and is primarily expressed in stratified epithelial tissues, though its expression patterns and functional roles remain less characterized compared to other keratins like KRT5 or KRT14. Studies suggest KRT22 may be involved in epithelial differentiation and barrier formation. Its dysregulation has been tentatively linked to certain epithelial pathologies, including inflammatory skin disorders and carcinomas, though conclusive evidence is limited. The KRT222 antibody is commonly used in immunohistochemistry (IHC) and Western blotting to localize and quantify KRT22 in tissue samples, aiding in investigations of epithelial biology and disease mechanisms. While commercial KRT222 antibodies are available for research, their specificity and applications may vary, necessitating validation via controls. Ongoing research aims to clarify KRT22's biological significance and potential as a diagnostic or therapeutic target.

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