| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MPYCD; BRP44L; CGI-129; dJ68L15.3 |
| WB Predicted band size | 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇涉及MPC1抗体的研究文献摘要概述：
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1. **文献名称**: *Mitochondrial pyruvate carrier 1 (MPC1) antibody validation in human tissues*
**作者**: Smith J, et al.
**摘要**: 该研究通过Western blot和免疫组化验证了多种商业MPC1抗体在人类心脏、肝脏及肿瘤组织中的特异性，发现不同抗体存在交叉反应性差异，强调选择可靠抗体对研究MPC1蛋白表达的重要性。
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2. **文献名称**: *MPC1 deficiency promotes colorectal cancer progression via reducing lipid oxidation*
**作者**: Chen L, et al.
**摘要**: 使用MPC1特异性抗体检测结直肠癌组织中蛋白表达水平，发现MPC1低表达与患者预后不良相关，并通过代谢组学分析揭示其通过抑制脂肪酸氧化促进肿瘤生长的机制。
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3. **文献名称**: *A novel monoclonal antibody targeting MPC1 for metabolic reprogramming studies*
**作者**: Kim H, et al.
**摘要**: 报道了一种新型单克隆MPC1抗体的开发，验证其在流式细胞术和免疫荧光中的高特异性，并应用于肺癌细胞模型，证明抑制MPC1导致糖酵解增强和线粒体呼吸抑制。
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**备注**：以上文献为示例性质，实际引用时需根据具体研究领域补充真实文献信息(可通过PubMed/Google Scholar搜索“MPC1 antibody”或“MPC1 mitochondrial pyruvate carrier”获取)。
The mitochondrial pyruvate carrier 1 (MPC1) is a key protein embedded in the inner mitochondrial membrane, responsible for transporting pyruvate into the mitochondrial matrix—a critical step linking glycolysis to the tricarboxylic acid (TCA) cycle and oxidative phosphorylation. MPC1 forms a heterocomplex with MPC2. and its dysfunction is implicated in metabolic disorders, cancer, and neurodegenerative diseases. Antibodies targeting MPC1 are essential tools for studying its expression, localization, and regulatory roles in cellular metabolism.
MPC1 antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels in tissues or cultured cells, particularly under conditions of metabolic stress or disease. Research has shown that reduced MPC1 expression correlates with metabolic reprogramming in cancers (the Warburg effect) and insulin resistance in diabetes. Additionally, these antibodies help explore MPC1's role in neurological conditions, such as Alzheimer’s disease, where mitochondrial dysfunction is a hallmark.
The development of MPC1 antibodies has advanced understanding of mitochondrial biology and disease mechanisms, offering potential for therapeutic targeting. However, challenges remain in standardizing antibody specificity across experimental models. Overall, MPC1 antibodies remain pivotal in elucidating the interplay between mitochondrial metabolism and human health.
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