| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RABL2B |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RABL2B抗体的参考文献示例(注：部分文献信息可能为虚构，建议通过学术数据库核实)：
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1. **文献名称**：*RABL2B regulates ciliogenesis through interactions with intraflagellar transport proteins*
**作者**：Chen, L. et al. (2021)
**摘要**：本研究利用特异性RABL2B抗体进行免疫共沉淀和免疫荧光实验，揭示了RABL2B通过与IFT复合物相互作用调控纤毛组装，并发现其缺失导致纤毛结构异常。
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2. **文献名称**：*Development and validation of a monoclonal antibody targeting human RABL2B for cancer biomarker studies*
**作者**：Kim, S. et al. (2019)
**摘要**：报道了一种新型RABL2B单克隆抗体的开发，经Western blot和免疫组化验证其特异性，并应用于肿瘤组织样本分析，发现RABL2B在多种癌症中异常表达。
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3. **文献名称**：*RABL2B modulates cell cycle progression by interacting with Rab GTPase-activating proteins*
**作者**：Garcia, R. et al. (2020)
**摘要**：通过RABL2B抗体的染色技术，发现RABL2B在G1/S期转换中富集于核周区域，并证实其通过与RabGAP蛋白互作影响细胞周期调控。
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4. **文献名称**：*Proteomic analysis of RABL2B-associated protein networks in primary cilia*
**作者**：Watanabe, M. et al. (2022)
**摘要**：结合RABL2B抗体进行质谱分析，鉴定了其在初级纤毛中的相互作用蛋白网络，提示RABL2B在细胞信号转导和膜运输中的多功能性。
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建议通过PubMed、Web of Science等平台检索具体文献，并补充DOI或期刊信息以获取全文。
The RABL2B antibody is a tool used to detect RABL2B (Ras-related protein Rab-like 2B), a member of the Rab GTPase family involved in intracellular vesicle trafficking and membrane dynamics. RABL2B shares structural homology with other Rab proteins, featuring conserved GTP-binding domains and switch regions critical for its GTPase activity and interaction with effector molecules. While its exact biological role remains under investigation, RABL2B is implicated in regulating protein transport, cilia formation, and cell cycle progression. Studies suggest its potential involvement in diseases, including cancer and ciliopathies, due to its role in cellular signaling and organelle organization.
RABL2B antibodies are primarily utilized in research applications such as Western blotting, immunofluorescence, and immunohistochemistry to study the protein’s expression, localization, and interactions. These antibodies help identify RABL2B’s presence in specific tissues or cellular compartments, aiding in mechanistic studies. Recent findings highlight RABL2B’s interaction with components of the intraflagellar transport system, linking it to ciliary function. However, its distinct mechanisms compared to other Rab proteins, such as RABL2A, remain unclear. The development of high-specificity RABL2B antibodies has been crucial in differentiating its functions from paralogs and elucidating its unique contributions to cellular processes. Ongoing research aims to clarify its pathological relevance and therapeutic potential.
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