Rabbit Polyclonal RPL35A Antibody

The RPL35A antibody is a crucial tool for studying the ribosomal protein L35a, encoded by the RPL35A gene. As a component of the 60S ribosomal subunit, RPL35A plays a role in protein synthesis by facilitating ribosome assembly and mRNA translation. This antibody is widely used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to detect RPL35A expression and localization in cells or tissues. Research has linked RPL35A dysregulation to human diseases, including Diamond-Blackfan anemia (DBA), a rare bone marrow failure disorder often caused by mutations in ribosomal protein genes. Additionally, RPL35A overexpression has been observed in certain cancers, suggesting its potential as a biomarker or therapeutic target. The antibody’s specificity is validated through knockdown/knockout controls, ensuring accurate detection of the ~14 kDa protein. Beyond basic research, it aids in exploring ribosomopathies, cancer biology, and cellular stress responses, where ribosomal function is critical. Commercial RPL35A antibodies are typically developed in rabbits or mice, with reactivity across human, mouse, and rat samples, supporting cross-species studies. Its application extends to developmental biology, given ribosomes' essential role in growth and differentiation.