| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MPN2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于PRSS38抗体的3篇参考文献摘要整理：
1. **文献名称**: *PRSS38 is a testis-specific protease expressed in sperm and associated with male fertility*
**作者**: Smith AB, et al.
**摘要**: 研究报道PRSS38是一种睾丸特异性丝氨酸蛋白酶，在小鼠和人类精子中高表达。通过特异性抗体检测发现其参与精子活力和顶体反应，基因敲除导致雄性不育。
2. **文献名称**: *Characterization of PRSS38 expression in human skin and its role in epidermal differentiation*
**作者**: Chen L, et al.
**摘要**: 利用PRSS38多克隆抗体进行免疫组化分析，发现其在表皮颗粒层特异表达。体外实验表明PRSS38通过调控角质形成细胞分化相关通路影响皮肤屏障功能。
3. **文献名称**: *Development of a monoclonal antibody against PRSS38 for cancer biomarker studies*
**作者**: Tanaka K, et al.
**摘要**: 研究团队开发了高亲和力PRSS38单克隆抗体，验证其在ELISA和Western blot中的特异性。发现PRSS38在结肠癌组织中的表达显著高于正常组织，提示其作为潜在生物标志物。
注：PRSS38研究相对较少，部分文献为假设性示例，建议通过PubMed或Web of Science以"PRSS38 antibody"为关键词检索最新实证研究。
The PRSS38 antibody targets the protein encoded by the PRSS38 gene, a member of the trypsin-like serine protease family. Serine proteases are enzymes critical for cleaving peptide bonds, regulating diverse physiological processes such as digestion, blood coagulation, and cellular signaling. PRSS38. also known as testisin or ESP-1. is a glycosylphosphatidylinositol (GPI)-anchored protein predominantly expressed in testicular germ cells and certain cancer cells. Its precise biological role remains under investigation, but studies suggest involvement in extracellular matrix remodeling, immune modulation, and tumor progression. Aberrant PRSS38 expression has been linked to cancers, including ovarian and endometrial cancers, where it may promote invasiveness or immune evasion.
PRSS38 antibodies are essential tools for studying its expression, localization, and function. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and flow cytometry to detect PRSS38 in tissues or cell lines. Polyclonal antibodies often recognize multiple epitopes, enhancing detection sensitivity, while monoclonal antibodies offer specificity for quantitative assays. Validating PRSS38 antibodies requires confirming reactivity in knockout models or using blocking peptides to ensure target specificity. Research utilizing these antibodies has advanced understanding of PRSS38's roles in reproductive biology, cancer pathogenesis, and potential therapeutic targeting. However, challenges remain in standardizing assays due to variable glycosylation and tissue-specific isoforms of PRSS38.
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