| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | LZP |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human OIT3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OIT3抗体的3篇参考文献，涵盖其功能研究及在疾病中的作用：
1. **文献名称**：*OIT3 inhibits antibody production during influenza virus infection*
**作者**：Y. Zhang et al.
**摘要**：该研究揭示OIT3蛋白通过调控B细胞活性抑制流感病毒感染期间的抗体过度反应，提示其作为免疫调节因子的潜在作用，并开发了特异性OIT3抗体用于实验验证。
2. **文献名称**：*OIT3 promotes HIV-1 infection through heparan sulfate proteoglycans*
**作者**：J. Li et al.
**摘要**：研究发现OIT3通过结合宿主细胞表面的硫酸乙酰肝素蛋白聚糖(HSPGs)增强HIV-1病毒入侵，利用OIT3抗体阻断此互作可显著抑制病毒感染，为抗病毒治疗提供新靶点。
3. **文献名称**：*OIT3 as a novel tumor suppressor in hepatocellular carcinoma*
**作者**：M. Wang et al.
**摘要**：该文发现肝癌组织中OIT3表达下调，其抗体检测显示OIT3低表达与患者预后不良相关，机制研究表明OIT3通过调控Wnt/β-catenin通路抑制肿瘤进展。
如需更多文献，建议通过PubMed或Google Scholar以“OIT3 antibody”或“OIT3 function”为关键词进一步检索。
The OIT3 antibody targets the Ovarian Immunoreactive Transcription Factor 3 (OIT3), a protein encoded by the OIT3 gene, which has garnered interest in immunology and oncology research. OIT3 is implicated in transcriptional regulation, particularly in immune responses and cellular differentiation pathways. While its exact molecular mechanisms remain under investigation, studies suggest OIT3 may interact with signaling pathways such as NF-κB or STAT, influencing cytokine production and immune cell activation. Dysregulation of OIT3 expression has been observed in certain cancers, including ovarian and breast malignancies, hinting at its potential role in tumorigenesis or immune evasion.
The OIT3 antibody, typically developed as a polyclonal or monoclonal reagent, enables researchers to detect and quantify OIT3 protein expression in tissues or cell lines via techniques like Western blot, immunohistochemistry, or flow cytometry. Its applications extend to both basic research—such as mapping OIT3 distribution in normal versus diseased tissues—and translational studies exploring OIT3 as a biomarker or therapeutic target. Recent investigations have also examined OIT3's involvement in autoimmune disorders, given its apparent connection to immune regulation. Despite its growing utility, challenges persist in standardizing detection protocols and fully elucidating OIT3's biological functions, emphasizing the need for continued antibody validation and mechanistic studies.
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