| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | TMG3; PRGP3 |
| WB Predicted band size | 26 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是我模拟的3篇关于PRRG3抗体的假想参考文献(请注意实际文献需通过学术数据库验证)：
1. **文献名称**: "PRRG3 regulates platelet-derived growth factor receptor signaling and cell migration"
**作者**: Li X, et al.
**摘要**: 本研究利用特异性PRRG3抗体，发现PRRG3通过调控PDGFRβ的磷酸化影响细胞迁移，揭示了其在肿瘤微环境中的作用机制。
2. **文献名称**: "Proline-rich Gla protein 3 (PRRG3) is a novel biomarker in glioblastoma"
**作者**: Chen H, et al.
**摘要**: 通过免疫组化(使用兔源PRRG3多克隆抗体)，证实PRRG3在胶质母细胞瘤中高表达，并与患者预后不良显著相关。
3. **文献名称**: "PRRG3 interacts with γ-secretase and modulates amyloid-β production"
**作者**: Wang Y, et al.
**摘要**: 研究通过Western blot(使用小鼠单克隆PRRG3抗体)证明PRRG3与γ-分泌酶复合物结合，可能参与阿尔茨海默病的Aβ病理过程。
4. **文献名称**: "Tissue-specific expression pattern of PRRG3 revealed by antibody-based profiling"
**作者**: Human Protein Atlas Consortium
**摘要**: 基于PRRG3抗体的组织芯片分析显示，该蛋白在肾脏、胎盘和大脑中高表达，提示其器官发育中的潜在功能。
**注意**：以上文献为模拟示例，实际研究中请通过PubMed/Google Scholar等平台，以关键词"PRRG3 antibody"+"gene function"检索真实文献，重点关注抗体应用场景(如WB/IHC)及疾病关联研究。
PRRG3 (Proline Rich and Gla Domain 3) is a transmembrane protein belonging to the proline-rich gamma-carboxyglutamic acid (Gla) protein family. It features an N-terminal Gla domain, which undergoes vitamin K-dependent post-translational modification, and a C-terminal proline-rich region. PRRG3 is implicated in cellular processes such as cell adhesion, signaling, and protein-protein interactions, though its precise biological functions remain under investigation. Emerging studies suggest its involvement in tumorigenesis, with altered expression observed in cancers like breast and lung adenocarcinoma, where it may influence cell proliferation or metastasis.
PRRG3 antibodies are essential tools for detecting and characterizing this protein in research. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study PRRG3 expression patterns, subcellular localization, and interactions. Some studies highlight PRRG3's potential role in neurological disorders and vascular biology, possibly linked to its expression in brain tissues and endothelial cells. Despite progress, the regulatory mechanisms of PRRG3 and its pathophysiological relevance require further exploration. Antibodies against PRRG3 thus serve as critical reagents for unraveling its functional roles and evaluating its potential as a diagnostic marker or therapeutic target in diseases.
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