| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/60-1/450 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | APS2; DIPP3a; DIPP3-alpha |
| WB Predicted band size | 19 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NUDT10抗体的3篇参考文献示例(注：以下内容为模拟生成，实际文献需通过学术数据库查询)：
1. **文献名称**: "Characterization of NUDT10 as a redox-sensitive phosphatase and its interaction with cellular oxidative stress pathways"
**作者**: Smith J, et al. (2020)
**摘要**: 该研究利用特异性NUDT10抗体，通过Western blot和免疫荧光技术，揭示了NUDT10在细胞核和线粒体中的定位，并证明其通过水解氧化损伤的核苷酸(如8-oxo-dGTP)参与细胞氧化应激应答。
2. **文献名称**: "NUDT10 overexpression correlates with poor prognosis in colorectal cancer: An immunohistochemical study"
**作者**: Zhang L, et al. (2021)
**摘要**: 研究通过开发高特异性NUDT10单克隆抗体，对结直肠癌组织进行免疫组化分析，发现NUDT10的高表达与肿瘤转移和患者生存率降低显著相关，提示其可能作为癌症预后标志物。
3. **文献名称**: "Development of a monoclonal antibody against NUDT10 for functional studies in neurodegenerative models"
**作者**: Johnson R, et al. (2019)
**摘要**: 该文献报道了一种新型NUDT10单克隆抗体的开发与验证，通过免疫沉淀和体外酶活实验，证实NUDT10在阿尔茨海默病模型神经元中表达下调，可能影响DNA氧化损伤修复过程。
4. **文献名称**: "NUDT10 antibody-based detection in human tissues reveals organ-specific expression patterns"
**作者**: Lee S, et al. (2022)
**摘要**: 利用多克隆NUDT10抗体对多种人体组织进行系统性分析，发现其在代谢活跃器官(如肝脏、肾脏)中高表达，支持其在核苷酸代谢稳态中的关键作用。
(注：以上文献信息为示例性模拟，实际引用请参考PubMed、Web of Science等数据库的最新研究。)
**Background of NUDT10 Antibody**
The NUDT10 antibody is a research tool designed to detect and study NUDT10 (Nudix Hydrolase 10), a member of the Nudix hydrolase family. NUDT10. also known as diadenosine hexaphosphate hydrolase, is an enzyme involved in hydrolyzing specific nucleotide substrates, including diadenosine polyphosphates (ApₙA) and diphosphoinositol phosphates (DIPs). These substrates play roles in cellular signaling, stress responses, and metabolic regulation.
NUDT10 is implicated in modulating redox signaling and nucleotide pool balance, impacting processes such as DNA repair, apoptosis, and cell proliferation. Its dysregulation has been linked to oxidative stress-related pathologies, cancer, and neurodegenerative disorders. The NUDT10 antibody facilitates the investigation of its expression, localization, and function in various tissues and disease models.
Typically generated in rabbits or mice using immunogenic peptides or recombinant proteins, this antibody is validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. Specificity is confirmed through knockout controls or siRNA knockdown. Research utilizing NUDT10 antibodies contributes to understanding its role in cellular homeostasis, disease mechanisms, and potential therapeutic targeting. Ongoing studies aim to clarify its substrate preferences, regulatory pathways, and interactions within metabolic networks.
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