| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MTH3 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Rat |
| Immunogen | Fusion protein of human NUDT18 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NUDT18抗体的3篇参考文献示例(基于公开信息推测，部分内容可能需要核实)：
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1. **文献名称**: *Characterization of NUDT18 as a novel regulator of nucleotide homeostasis*
**作者**: Smith A, et al. (2020)
**摘要**: 本研究首次报道了NUDT18蛋白在核苷酸代谢中的作用，通过特异性抗体验证其在小鼠肝脏组织中的表达及亚细胞定位，并发现其通过水解特定核苷酸维持细胞稳态。
2. **文献名称**: *Development of a monoclonal antibody against human NUDT18 for immunohistochemical analysis*
**作者**: Tanaka K, et al. (2018)
**摘要**: 作者开发了一种高特异性抗人NUDT18的单克隆抗体，验证其在石蜡包埋组织中的适用性，发现NUDT18在多种肿瘤组织中表达异常，提示其潜在临床诊断价值。
3. **文献名称**: *NUDT18 interacts with DNA repair complexes: Insights from antibody-based proteomic screening*
**作者**: García-Sánchez F, et al. (2021)
**摘要**: 利用NUDT18抗体进行免疫共沉淀-质谱分析，揭示了NUDT18与BRCA1复合物的相互作用，表明其可能在DNA损伤修复通路中发挥功能。
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**注意**：以上为模拟参考文献，实际文献需通过PubMed/Google Scholar等平台检索确认。建议使用关键词“NUDT18 antibody”或“NUDT18 + immunoblotting/immunohistochemistry”查询最新研究。
The NUDT18 antibody is a research tool designed to target the NUDT18 protein, a member of the NUDIX hydrolase family. NUDT18. also known as dATPase, is an enzyme involved in nucleotide metabolism, particularly hydrolyzing oxidized or damaged nucleotides like dATP to maintain cellular homeostasis. This function suggests its role in regulating nucleotide pools, DNA repair, and redox balance, with potential implications in cancer, aging, and neurodegenerative diseases.
The development of NUDT18 antibodies enables the study of its expression, localization, and interactions in various biological contexts. Researchers use these antibodies in techniques such as Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate NUDT18's tissue-specific distribution, expression levels under stress conditions, or disease states. Commercial NUDT18 antibodies are typically generated using immunogens like recombinant proteins or synthetic peptides, validated for specificity and sensitivity.
Studies employing NUDT18 antibodies have explored its regulatory roles in cell proliferation, apoptosis, and response to oxidative damage. For instance, altered NUDT18 expression has been linked to cancer progression, where dysregulated nucleotide metabolism may drive genomic instability. Reliable antibodies are critical for elucidating its molecular mechanisms and therapeutic potential. However, cross-reactivity with other NUDIX family members remains a concern, necessitating rigorous validation. Overall, NUDT18 antibodies serve as essential tools for advancing understanding of nucleotide metabolism and related pathologies.
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