| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CFM2; FAM101A |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human RFLNA |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RFLNA抗体的模拟参考文献示例(注：RFLNA相关研究较为冷门，以下内容为假设性示例，建议核实具体术语或补充背景信息)：
1. **文献名称**：*Autoantibodies to RFLNA in Systemic Lupus Erythematosus: Clinical Correlations*
**作者**：Chen L, et al.
**摘要**：本研究检测了系统性红斑狼疮(SLE)患者血清中抗RFLNA抗体的表达水平，发现其与疾病活动度(如肾脏受累)显著相关，提示RFLNA可能作为SLE的新型生物标志物。
2. **文献名称**：*RFLNA as a Novel Tumor-Associated Antigen in Colorectal Cancer*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化分析，研究发现RFLNA在结直肠癌组织中高表达，且患者血清中抗RFLNA抗体水平升高，可能与肿瘤免疫逃逸机制相关。
3. **文献名称**：*RFLNA Antibody Profiling in Viral Infections: Insights from a Cohort Study*
**作者**：Gupta S, et al.
**摘要**：探索了EB病毒和HIV感染者中抗RFLNA抗体的存在情况，发现其与慢性炎症状态相关，为病毒感染后自身免疫反应的机制提供新线索。
**建议**：若需真实文献，请确认术语准确性(如是否为**RFPLNA**或其他类似缩写)，或补充研究背景(如疾病领域)。可进一步检索PubMed/Google Scholar使用关键词组合(如RFLNA + autoantibody/disease-specific term)。
The RFLNA (Ret Finger-Like Protein N-Terminal Associated) antibody targets a protein belonging to the RFPL family, characterized by a RING-finger domain critical for E3 ubiquitin ligase activity. These proteins are implicated in ubiquitination pathways, regulating processes like protein degradation, DNA repair, and cell cycle control. RFLNA, specifically, is less studied compared to other family members (e.g., RFPL1-3), but emerging research links it to neurodevelopment and germ cell maturation. It is highly expressed in the brain and testes, suggesting roles in neuronal differentiation or spermatogenesis.
Antibodies against RFLNA are primarily used in research to investigate its expression patterns, interactions, and functional mechanisms. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry, aiding in localization studies within tissues or subcellular compartments. Dysregulation of RFLNA has been tentatively associated with neurological disorders and infertility, though mechanistic insights remain limited.
Commercial RFLNA antibodies are typically raised in rabbits or mice using synthetic peptides or recombinant protein fragments. Validation includes specificity tests (knockout controls) and application-based assays. Challenges include cross-reactivity due to homology within the RFPL family. Ongoing studies aim to clarify RFLNA’s role in ubiquitination networks and disease, positioning it as a potential biomarker or therapeutic target.
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