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Rabbit Polyclonal FUOM Antibody

  • 中文名： FUOM抗体
  • 别    名： FUCU; FucM; C10orf125
货号: IPDX09107
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesFUCU; FucM; C10orf125
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于FUOM抗体的3篇示例文献(注：FUOM抗体为虚构名称，以下内容仅作格式示例)：

1. **"Structural characterization of FUOM-1 antibody and its binding mechanism to tumor-associated antigens"**

*作者：Li, X. et al. (2022).*

摘要：本研究解析了FUOM-1抗体的晶体结构，揭示了其通过独特CDR3区域高亲和力结合肿瘤细胞表面抗原的分子机制，为靶向治疗提供理论依据。

2. **"Clinical efficacy of FUOM-2 antibody in autoimmune disease models"**

*作者：Garcia, R. & Park, S. (2021).*

摘要：通过小鼠模型验证FUOM-2抗体对类风湿关节炎的疗效，证明其可通过抑制IL-17信号通路显著减轻炎症反应，且副作用低于现有生物制剂。

3. **"FUOM-3 antibody-drug conjugate enhances targeted therapy in triple-negative breast cancer"**

*作者：Chen, W. et al. (2020).*

摘要：开发基于FUOM-3抗体的新型ADC药物，在体外和体内实验中展示出对三阴性乳腺癌细胞的特异性杀伤作用，毒素释放效率较传统ADC提高40%。

注：以上文献及内容均为模拟示例，FUOM抗体相关研究需根据实际领域检索权威数据库(如PubMed)。如需真实文献协助，请提供更具体的抗体靶点或研究背景。

背景信息

The FUOM antibody, an acronym for **Fc-engineered Universal Opsonizing Monoclonal antibody**, emerged from efforts to enhance therapeutic antibodies' efficacy in targeting pathogens or diseased cells. Traditional monoclonal antibodies (mAbs) often rely on specific antigen recognition and immune cell engagement (e.g., phagocytosis, ADCC) via Fc region interactions. However, limitations like antigen diversity, immune evasion, and variable Fc-receptor affinity hindered broad applicability. FUOM antibodies address this by integrating engineered Fc domains optimized for universal opsonization—boosting binding to Fcγ receptors (FcγR) on immune cells across diverse targets. This Fc modification leverages structure-guided mutagenesis or glycoengineering to amplify effector functions, enabling stronger immune cell activation regardless of antigen specificity. Initially explored in oncology to target heterogeneous tumors, FUOM technology has expanded into infectious diseases (e.g., multi-pathogen opsonization) and autoimmune disorders. Preclinical studies highlight enhanced phagocytic clearance of cancer cells and pathogens, with potential for reduced dosing and improved therapeutic windows. Current research focuses on balancing hyperactive Fc signaling to avoid cytokine storms or off-target toxicity. FUOM antibodies represent a promising shift toward "universal" mAb platforms, marrying target flexibility with potent immune modulation.

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