Rabbit Polyclonal ZNRD1 Antibody

The zinc ribbon domain-containing 1 (ZNRD1) antibody is a tool used to detect ZNRD1. a protein encoded by the ZNRD1 gene located on human chromosome 6p21.3. ZNRD1. also known as DNA-directed RNA polymerase I subunit RPA12. is a nuclear protein involved in ribosomal RNA synthesis as part of RNA polymerase I. Studies suggest its role in cell proliferation, apoptosis, and immune regulation, with implications in cancer biology. ZNRD1 is overexpressed in certain malignancies, including gastric cancer and leukemia, and may influence drug resistance mechanisms, such as cisplatin sensitivity. Additionally, ZNRD1 interacts with HLA class I molecules, linking it to immune response modulation. The antibody, typically developed in hosts like rabbit or mouse, enables researchers to study ZNRD1's expression patterns, subcellular localization, and functional pathways via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications span cancer research, immunology, and studies of ribosomal biogenesis. Validated ZNRD1 antibodies are critical for elucidating the protein's dual roles in tumor progression and immune evasion, potentially aiding biomarker discovery or therapeutic targeting. Commercial availability and specificity validation (e.g., knockout validation) remain essential considerations for experimental reliability.