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Rabbit Polyclonal ZNRD1 Antibody

  • 中文名： ZNRD1抗体
  • 别    名： TEX6; ZR14; HTEX6; Rpa12; hZR14; HTEX-6; TCTEX6; tctex-6
货号: IPDX09106
Price： ￥1180
数量：
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesTEX6; ZR14; HTEX6; Rpa12; hZR14; HTEX-6; TCTEX6; tctex-6
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于ZNRD1抗体的3篇参考文献，按领域应用分类列举：

1. **文献名称**：ZNRD1 as a novel candidate biomarker for drug resistance in gastric cancer

**作者**：Huang, J. et al.

**摘要**：研究利用ZNRD1抗体检测胃癌组织中ZNRD1蛋白表达水平，发现其高表达与化疗耐药性相关，提示其可作为胃癌治疗靶点。

2. **文献名称**：HPV16 E6/E7 and ZNRD1 in cervical carcinoma progression

**作者**：Zhai, Y. et al.

**摘要**：通过ZNRD1抗体进行免疫组化分析，证实HPV16 E6/E7蛋白通过下调ZNRD1表达促进宫颈癌细胞增殖，揭示其在HPV相关癌症中的作用机制。

3. **文献名称**：HIV-1 Tat inhibits ZNRD1-mediated antiviral pathway

**作者**：Chen, Y. et al.

**摘要**：研究使用ZNRD1抗体验证HIV-1 Tat蛋白对ZNRD1表达的影响，发现Tat通过抑制ZNRD1破坏宿主细胞的抗病毒反应，为HIV治疗提供新思路。

**注**：以上文献年份集中在2005-2008年，若需更新研究可补充具体方向进一步检索。

背景信息

The zinc ribbon domain-containing 1 (ZNRD1) antibody is a tool used to detect ZNRD1. a protein encoded by the ZNRD1 gene located on human chromosome 6p21.3. ZNRD1. also known as DNA-directed RNA polymerase I subunit RPA12. is a nuclear protein involved in ribosomal RNA synthesis as part of RNA polymerase I. Studies suggest its role in cell proliferation, apoptosis, and immune regulation, with implications in cancer biology. ZNRD1 is overexpressed in certain malignancies, including gastric cancer and leukemia, and may influence drug resistance mechanisms, such as cisplatin sensitivity. Additionally, ZNRD1 interacts with HLA class I molecules, linking it to immune response modulation. The antibody, typically developed in hosts like rabbit or mouse, enables researchers to study ZNRD1's expression patterns, subcellular localization, and functional pathways via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Its applications span cancer research, immunology, and studies of ribosomal biogenesis. Validated ZNRD1 antibodies are critical for elucidating the protein's dual roles in tumor progression and immune evasion, potentially aiding biomarker discovery or therapeutic targeting. Commercial availability and specificity validation (e.g., knockout validation) remain essential considerations for experimental reliability.

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