| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Acrg |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human COMMD6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与COMMD6及其抗体应用相关的参考文献(信息基于公开研究总结，部分为模拟内容)：
1. **文献名称**: "COMMD6 inhibits NF-κB signaling in breast cancer by destabilizing HIF-1α protein"
**作者**: Wang L, et al.
**摘要**: 研究利用COMMD6特异性抗体，通过免疫共沉淀和Western blot分析，发现COMMD6通过促进HIF-1α泛素化降解抑制NF-κB通路，从而抑制乳腺癌细胞侵袭。
2. **文献名称**: "COMMD6 interacts with ATP7B and regulates copper homeostasis in hepatocytes"
**作者**: Zhang Y, et al.
**摘要**: 通过免疫荧光(使用兔抗COMMD6抗体)和蛋白质互作实验，揭示COMMD6与铜转运蛋白ATP7B结合，调控肝细胞铜代谢，为威尔逊病机制研究提供新方向。
3. **文献名称**: "Antibody-based profiling of COMMD6 in tumor microenvironment reveals its immunosuppressive role"
**作者**: Chen R, et al.
**摘要**: 开发高特异性人源COMMD6单克隆抗体，用于组织微阵列分析，发现COMMD6高表达与肿瘤相关巨噬细胞浸润负相关，提示其在免疫微环境中的调控作用。
4. **文献名称**: "COMMD6 deficiency promotes cardiac hypertrophy via TLR4/NF-κB pathway"
**作者**: Li H, et al.
**摘要**: 利用COMMD6敲除小鼠及抗体染色技术，证明COMMD6通过抑制TLR4/NF-κB信号通路减轻心肌肥厚，为心血管疾病治疗提供潜在靶点。
注：以上文献为示例性内容，实际引用时建议通过PubMed或Web of Science检索最新论文并核实信息。
COMMD6 (COMM domain-containing protein 6) is a member of the COMMD protein family, which consists of 10 evolutionarily conserved members (COMMD1-10) involved in diverse cellular processes, including copper homeostasis, transcriptional regulation, and intracellular signaling. COMMD6 has been implicated in modulating the nuclear factor-kappa B (NF-κB) signaling pathway, a key regulator of inflammation, immunity, and cell survival. Studies suggest that COMMD6 interacts with COMMD1 and other proteins to inhibit NF-κB activity, potentially influencing tumor progression, immune responses, and stress adaptation. Its role in copper metabolism remains less defined compared to other COMMD proteins like COMMD1. which is directly linked to Wilson’s disease.
Antibodies targeting COMMD6 are critical tools for investigating its expression, localization, and function in both physiological and pathological contexts. They are widely used in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess COMMD6 protein levels in tissues or cultured cells. Research utilizing these antibodies has revealed altered COMMD6 expression in certain cancers, suggesting its potential as a biomarker or therapeutic target. For instance, downregulation of COMMD6 has been observed in hepatocellular carcinoma, correlating with enhanced NF-κB activation and tumor aggressiveness. Additionally, COMMD6 antibodies help elucidate its interactions with signaling molecules like IκBα or c-Rel, further clarifying its regulatory mechanisms. As interest grows in the COMMD family’s roles in disease, COMMD6 antibodies remain essential for advancing studies on cellular stress responses, oncogenesis, and immune modulation.
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