Rabbit Polyclonal PIN4 Antibody

The PIN4 antibody targets the protein phosphatase 2A (PP2A) inhibitor protein, also known as Phosphatase Inhibitor-4 (PIN4), encoded by the *PPP1R10* gene. PIN4 regulates PP2A, a critical serine/threonine phosphatase involved in diverse cellular processes, including cell cycle progression, signal transduction, and apoptosis. PIN4 contains multiple TPR (tetratricopeptide repeat) domains, enabling interactions with PP2A and other partners like Prohibitin-1/2. modulating PP2A activity in a context-dependent manner. Dysregulation of PIN4 has been implicated in cancer, particularly prostate cancer, where PIN4 overexpression inhibits PP2A-mediated dephosphorylation of oncogenic kinases (e.g., AKT), promoting cell survival and proliferation. PIN4 also localizes to mitochondria, influencing energy metabolism and stress responses. Antibodies against PIN4 are widely used in research to study its expression, subcellular localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. These tools help elucidate PIN4’s role in PP2A regulation, mitochondrial function, and disease mechanisms. Recent studies also explore PIN4 as a potential therapeutic target, given its dual role in tumor suppression and oncogenesis depending on cellular context.