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Rabbit Polyclonal SYCE3 Antibody

  • 中文名: SYCE3抗体
  • 别    名: THEG2; C22orf41
货号: IPDX09109
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/20-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

AliasesTHEG2; C22orf41
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse
ImmunogenFull length fusion protein
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于SYCE3抗体的3篇参考文献示例(注:文献为虚构,仅作格式参考):

1. **文献名称**:SYCE3 Antibody Characterization in Meiotic Chromosome Synapsis

**作者**:Smith A, et al.

**摘要**:本研究开发了一种针对SYCE3蛋白的多克隆抗体,并通过免疫荧光和Western blot验证其特异性。实验表明,SYCE3在减数分裂早期定位于联会复合体中央区域,其表达缺失导致小鼠生殖细胞联会异常。

2. **文献名称**:Role of SYCE3 in Human Spermatogenesis: Insights from Antibody-Based Profiling

**作者**:Chen L, et al.

**摘要**:利用SYCE3特异性单克隆抗体,作者分析了人类睾丸组织中SYCE3的时空表达模式,发现其与联会复合体形成密切相关,并在非梗阻性无精症患者中观察到SYCE3表达异常。

3. **文献名称**:SYCE3 Interaction Network Revealed by Co-Immunoprecipitation Studies

**作者**:Wang X, et al.

**摘要**:通过SYCE3抗体进行免疫共沉淀实验,鉴定出SYCE1、SYCE2等联会复合体相关蛋白为其相互作用伴侣,揭示了SYCE3在维持染色体配对中的分子机制。

(注:以上文献为示例性质,实际文献需通过PubMed/Google Scholar等平台检索确认。)

背景信息

The SYCE3 antibody targets the Synaptonemal Complex Central Element protein 3 (SYCE3), a crucial component of the synaptonemal complex (SC) formed during meiosis. The SC is a proteinaceous structure that mediates the pairing, alignment, and recombination of homologous chromosomes in gamete-producing cells. SYCE3. along with other SC proteins (e.g., SYCE1. SYCE2. TEX12), stabilizes the central element of the SC, ensuring proper synapsis and crossover formation between homologs. Research on SYCE3 antibodies primarily focuses on understanding meiosis regulation, fertility, and chromosomal abnormalities. These antibodies are used in techniques like immunofluorescence, Western blotting, or immunohistochemistry to visualize SYCE3 localization during meiotic prophase I or assess its expression levels. Dysregulation of SYCE3 is linked to meiotic defects, infertility, and conditions like aneuploidy (e.g., Down syndrome). Studying SYCE3 antibodies also aids in exploring reproductive disorders or developing diagnostic tools for gametogenesis-related pathologies. Their specificity and reliability make them vital tools in reproductive biology and genetic research.

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