| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RIG; S15 |
| WB Predicted band size | 17 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于RPS15抗体的3篇文献示例(注：以下内容为模拟生成的参考文献，实际文献需通过数据库检索确认)：
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1. **文献名称**: *RPS15 mutations in colorectal cancer promote ribosomal dysfunction and oncogenic transformation*
**作者**: Smith A, et al.
**摘要**: 本研究利用CRISPR筛选技术，发现RPS15基因在结直肠癌中高频突变，导致核糖体翻译保真度下降。通过RPS15抗体进行Western blot和免疫沉淀实验，证实突变体影响40S核糖体亚基组装，促进肿瘤细胞异常增殖。
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2. **文献名称**: *RPS15-mediated ribosomopathy in myelodysplastic syndromes*
**作者**: Chen L, et al.
**摘要**: 该研究通过患者样本测序发现RPS15的杂合突变与骨髓增生异常综合征(MDS)相关。使用RPS15抗体进行免疫组化分析，显示突变导致骨髓细胞核糖体应激加剧，激活p53通路并引发细胞凋亡。
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3. **文献名称**: *Antibody-based profiling of RPS15 overexpression in hepatocellular carcinoma*
**作者**: Wang Y, et al.
**摘要**: 通过组织芯片和RPS15特异性抗体分析肝癌样本，发现RPS15在肿瘤组织中显著高表达，且与患者预后不良相关。功能实验表明，敲低RPS15可抑制肝癌细胞迁移，提示其作为潜在治疗靶点。
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如需真实文献，建议通过PubMed或Google Scholar检索关键词“RPS15 antibody”或“RPS15 ribosome function”。
The RPS15 antibody is a key tool for studying the ribosomal protein S15 (RPS15), a component of the 40S subunit of eukaryotic ribosomes. RPS15 plays a critical role in ribosome biogenesis and protein synthesis, contributing to the structural stability of the ribosomal subunit and facilitating mRNA decoding. Beyond its canonical role in translation, RPS15 has been implicated in extra-ribosomal functions, including cellular stress responses, apoptosis regulation, and interactions with oncogenic signaling pathways. Dysregulation of RPS15 expression or mutations in the RPS15 gene have been linked to various cancers, such as chronic lymphocytic leukemia (CLL) and colorectal cancer, highlighting its potential as a therapeutic target or biomarker.
The RPS15 antibody is widely used in molecular biology and clinical research to detect and quantify RPS15 protein levels in cells or tissues. It is commonly employed in techniques like Western blotting, immunohistochemistry, immunofluorescence, and co-immunoprecipitation to investigate RPS15's localization, expression patterns, and protein-protein interactions. Researchers also utilize this antibody to explore the role of RPS15 in diseases, particularly in cancer progression and drug resistance mechanisms. Commercially available RPS15 antibodies are typically raised in hosts like rabbits or mice, with validation across multiple applications to ensure specificity. Its utility extends to both basic research on ribosome biology and translational studies aiming to uncover novel disease mechanisms.
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