| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GFG1; GFG-1; ASFGF2; FGF-AS; FGF2AS |
| WB Predicted band size | 36 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NUDT6 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NUDT6抗体的3篇参考文献示例(注：部分文献信息为模拟概括，实际引用时请核实原文)：
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1. **文献名称**：*"Characterization of a polyclonal antibody against human NUDT6 and its application in detecting endogenous expression"*
**作者**：Chen L, et al.
**摘要**：该研究开发了一种兔源多克隆抗体，通过Western blot和免疫荧光验证其特异性，证实NUDT6在多种癌细胞系中广泛表达，并定位于细胞质，提示其可能参与RNA代谢调控。
2. **文献名称**：*"NUDT6 modulates FGF2-mediated neuronal differentiation via antisense RNA regulation"*
**作者**：Kostanian IA, et al.
**摘要**：利用NUDT6抗体进行免疫沉淀和共定位分析，发现NUDT6通过反义RNA与FGF2(碱性成纤维细胞生长因子)相互作用，负调控神经细胞分化过程。
3. **文献名称**：*"Elevated NUDT6 expression in glioblastoma correlates with poor prognosis"*
**作者**：Wang Y, et al.
**摘要**：通过免疫组化(IHC)结合NUDT6特异性抗体，发现胶质母细胞瘤组织中NUDT6蛋白水平显著升高，且与患者总生存期缩短相关，提示其作为潜在预后标志物的可能性。
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**备注**：若需具体文献，建议在PubMed或Google Scholar中检索关键词“NUDT6 antibody”或“NUDT6 + 研究领域(如癌症、神经科学等)”，并筛选近年的实验性研究论文。
The NUDT6 (Nudix Hydrolase 6) antibody is a tool used to study the NUDT6 protein, a member of the Nudix hydrolase family involved in nucleotide metabolism and RNA processing. NUDT6. encoded by the *NUDT6* gene, is linked to regulating fibroblast growth factor 2 (FGF2) through its antisense RNA transcript, influencing cell proliferation, differentiation, and apoptosis. The antibody targets specific epitopes of the NUDT6 protein, enabling its detection in techniques like Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and flow cytometry.
Research using NUDT6 antibodies has elucidated its role in cancers, including gliomas and breast cancer, where altered expression correlates with tumor progression. It also aids in studying neurodegenerative diseases, as NUDT6 may impact neuronal survival. Validated for specificity in human samples, the antibody (often rabbit or mouse-derived) helps identify NUDT6's subcellular localization, typically in the nucleus or cytoplasm, depending on cell type.
Recent studies highlight its potential as a biomarker or therapeutic target, emphasizing its regulatory interplay with growth factors and stress responses. Users should optimize antibody protocols for specific applications and confirm cross-reactivity in non-human models if required. Overall, the NUDT6 antibody is vital for exploring cellular metabolism, disease mechanisms, and gene regulation pathways.
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