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Rabbit Polyclonal CNPY2 Antibody

  • 中文名: CNPY2抗体
  • 别    名: MSAP; TMEM4; ZSIG9; HP10390
货号: IPDX09134
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/25-1/100 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于CNPY2抗体的示例参考文献(注:部分为虚拟文献,供参考格式):

1. **文献名称**:*CNPY2 regulates endoplasmic reticulum stress and promotes tumor growth in hepatocellular carcinoma*

**作者**:Chen L, et al.

**摘要**:本研究利用CNPY2特异性抗体,通过免疫组化和Western blot分析肝癌组织中CNPY2的表达水平,发现其高表达与患者生存率降低相关。机制研究表明,CNPY2通过抑制内质网应激相关蛋白(如GRP78)促进肿瘤细胞增殖。

2. **文献名称**:*Development of a monoclonal antibody against human CNPY2 for functional studies in macrophages*

**作者**:Tanaka K, et al.

**摘要**:文章报道了一种新型抗人CNPY2单克隆抗体的制备与验证。该抗体成功用于流式细胞术和免疫共沉淀实验,揭示了CNPY2在巨噬细胞TLR4信号通路中的调控作用。

3. **文献名称**:*CNPY2 modulates synaptic plasticity via interaction with AMPA receptors*

**作者**:Park S, et al.

**摘要**:通过免疫荧光染色(使用CNPY2抗体)和基因敲除技术,研究发现CNPY2在海马神经元中与AMPA受体亚基结合,影响突触可塑性和学习记忆功能。

4. **文献名称**:*CNPY2 as a biomarker for early-stage lung adenocarcinoma: A tissue microarray study*

**作者**:Guo Y, et al.

**摘要**:基于组织微阵列和CNPY2抗体的免疫组化分析,研究发现CNPY2在早期肺腺癌中显著上调,提示其可作为潜在诊断标志物,并与EGFR信号通路激活相关。

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注:以上文献为示例性内容,实际引用时需以真实发表的论文为准。建议通过PubMed或Web of Science以关键词“CNPY2 antibody”或“CNPY2 function”检索最新文献。

背景信息

The CNPY2 (Canopy FGF Signaling Regulator 2) antibody is a research tool used to study the CNPY2 protein, a member of the conserved Canopy family implicated in cellular stress responses and protein quality control. CNPY2. also known as PRAT4B or C20orf31. is an endoplasmic reticulum (ER)-resident chaperone-like protein that interacts with unfolded protein response (UPR) mediators and modulates the stability or trafficking of membrane proteins, including Toll-like receptors (TLRs) and growth factor receptors. It plays roles in ER-associated degradation (ERAD), immune signaling, and cellular homeostasis. Dysregulation of CNPY2 has been linked to cancers, inflammatory diseases, and metabolic disorders. Antibodies targeting CNPY2 enable the detection and analysis of its expression, localization, and interactions via techniques like Western blotting, immunohistochemistry, and co-immunoprecipitation. These tools help elucidate CNPY2's involvement in pathological processes, such as tumor progression (e.g., promoting angiogenesis in glioblastoma) or metabolic dysfunction. Commercial CNPY2 antibodies are typically raised in rabbits or mice using immunogenic peptide sequences, with validation in specific applications. Research using CNPY2 antibodies contributes to understanding ER stress pathways and developing therapeutic strategies targeting UPR-related diseases.

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