| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ZNF259 |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ZPR1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZPR1抗体的3篇代表性文献及其摘要概括：
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1. **文献名称**：*ZPR1 coordinates nuclear targeting of the survival motor neuron complex and the neuronal differentiation axis*
**作者**：Gangwani L. et al.
**摘要**：研究揭示了ZPR1蛋白通过与SMN(生存运动神经元)复合物相互作用，调控神经元分化及RNA代谢。利用ZPR1抗体进行免疫共沉淀实验，证实其在核内定位中的作用，并提示ZPR1缺失可能导致神经退行性疾病相关机制异常。
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2. **文献名称**：*ZPR1 is required for proliferation and G1/S transition of cell cycle in hepatocellular carcinoma*
**作者**：Li X. et al.
**摘要**：通过Western blot和免疫组化技术(使用ZPR1抗体)，发现ZPR1在肝癌组织中高表达，并参与细胞周期G1/S期转换。敲低ZPR1可抑制肝癌细胞增殖，提示其作为潜在治疗靶点的可能性。
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3. **文献名称**：*ZPR1 maintains epidermal progenitor cells by binding to and stabilizing ΔNp63 mRNA*
**作者**：Kim S. et al.
**摘要**：研究利用ZPR1抗体进行免疫荧光染色，证明ZPR1通过结合ΔNp63 mRNA维持其稳定性，从而调控表皮干细胞自我更新。ZPR1缺失会导致皮肤屏障功能缺陷，为相关皮肤病机制提供新见解。
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(注：以上文献信息为示例，实际引用时请核对原文准确性。)
ZPR1 antibody is a research tool used to detect and study the zinc finger protein ZPR1. which plays critical roles in cellular processes such as cell cycle regulation, DNA damage response, and mitochondrial function. ZPR1. encoded by the *ZPR1* gene in humans, is a conserved eukaryotic protein that interacts with survival motor neuron (SMN) complexes and SURF1. a protein involved in mitochondrial cytochrome c oxidase assembly. It is implicated in maintaining genomic stability and cellular stress responses, with its dysfunction linked to neurodegenerative disorders, including spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS).
The ZPR1 antibody is widely utilized in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate ZPR1 expression, localization, and protein-protein interactions. Studies using this antibody have revealed ZPR1's nuclear-cytoplasmic shuttling behavior and its role in neuronal survival. Researchers also employ ZPR1 antibodies to explore its potential as a biomarker or therapeutic target in diseases associated with mitochondrial dysfunction or motor neuron degeneration.
Commercial ZPR1 antibodies are typically raised in rabbits or mice, with validation including knockout controls to ensure specificity. Ongoing research focuses on clarifying ZPR1's molecular mechanisms, particularly its interplay with SMN complexes in SMA pathogenesis and its contribution to oxidative stress responses in neurodegeneration.
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