关键信息
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基因名
GDF-15
- 应用
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别名
Macrophage inhibitory cytokine 1 (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor) (GDF-15)
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种属
Human
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表达系统
P. pastoris
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标签
N-10*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99988
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表达区间
197-308aa
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氨基酸序列
ARNGDHCPLGPGRCCRLHTVRASLEDLGWADWVLSPREVQVTMCIGACPSQFRAANMHAQIKTSLHRLKPDTVPAPCCVPASYNPMVLIQKTDTGVSLQTYDDLLAKDCHCI
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蛋白长度
Partial
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分子量
13.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, 5% Trehalose
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复溶方法
Reconstitute in ddH2O/PBS to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
质检流程
相关产品
背景信息
GDF-15 (Growth Differentiation Factor 15) is a member of the transforming growth factor-beta (TGF-β) superfamily and has emerged as a significant biomarker and therapeutic target in various diseases, including cancer, cardiovascular diseases, and metabolic disorders. Elevated levels of GDF-15 correlate with disease severity, making it a potential indicator of poor prognosis. Its role in regulating inflammation, apoptosis, and tissue repair further underscores its biological importance. Recent studies have highlighted its involvement in the cellular response to stress and injury, suggesting a protective mechanism that could be exploited for therapeutic purposes. As a result, the production of recombinant GDF-15 protein has garnered interest for both research and clinical applications. This involves utilizing advanced recombinant DNA technology to produce GDF-15 in suitable expression systems, allowing for the exploration of its physiological roles and potential as a therapeutic agent. Additionally, understanding the molecular pathways influenced by GDF-15 can provide insights into its mechanisms of action and aid in the development of targeted therapies. Hence, ongoing research revolves around refining its production, characterizing its biological functions, and evaluating its efficacy in preclinical and clinical settings, paving the way for innovative approaches to manage various diseases.
