| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ESP-2; HED-2 |
| WB Predicted band size | 61 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human ZYX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZYX抗体的3篇参考文献示例(注：文献为虚拟示例，实际引用需检索真实数据库)：
1. **文献名称**: "Zyxin Antibody-Based Detection of Focal Adhesion Dynamics in Live Cells"
**作者**: Smith J, et al.
**摘要**: 研究利用ZYX抗体标记活细胞中的黏着斑蛋白Zyxin，结合荧光成像技术揭示其在细胞迁移过程中与肌动蛋白骨架的动态互作机制。
2. **文献名称**: "Characterization of a Novel Monoclonal ZYX Antibody for Cardiovascular Tissue Analysis"
**作者**: Lee H, et al.
**摘要**: 报道一种新型ZYX单克隆抗体的开发与验证，证实其在心肌细胞中特异性识别Zyxin蛋白，并应用于心血管疾病模型中机械应力响应的分子机制研究。
3. **文献名称**: "Zyxin Antibody Reveals Its Role in Cancer Cell Invasion via Actin Remodeling"
**作者**: Garcia R, et al.
**摘要**: 通过ZYX抗体免疫组化分析，证明Zyxin在肿瘤细胞侵袭前沿高表达，调控肌动蛋白重塑，提示其作为癌症转移潜在生物标志物的可能性。
如需真实文献，建议在PubMed或Web of Science中检索关键词：**Zyxin antibody** + [应用领域，如focal adhesion/cancer/cardiovascular]。
Zyxin is a cytoskeletal protein primarily localized at focal adhesions and cell-cell junctions, where it plays a critical role in regulating cell adhesion, migration, and mechanotransduction. It interacts with components of the actin cytoskeleton, such as α-actinin and VASP, and shuttles between adhesion sites and the nucleus, potentially influencing gene expression in response to mechanical stimuli. Zyxin's function is vital in processes like tissue repair, embryonic development, and cancer metastasis, where cellular mechanics and signaling are pivotal.
The ZYX antibody is a research tool designed to detect and study zyxin expression and localization in various biological contexts. It is widely used in techniques like immunofluorescence, Western blotting, and immunohistochemistry to visualize zyxin's distribution in cells or tissues. Studies employing this antibody have elucidated zyxin's role in maintaining focal adhesion dynamics, mediating cellular responses to mechanical stress, and its involvement in pathological conditions, including fibrosis and tumor progression. For instance, reduced zyxin levels have been associated with impaired cell migration, while its overexpression is linked to enhanced metastatic potential in cancers.
As a target in mechanobiology research, zyxin and its associated antibody provide insights into how physical forces regulate cellular behavior, offering potential therapeutic avenues for diseases influenced by mechanical dysregulation.
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