| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DHRS6; EFA6R; SDR15C1; UCPA-OR; UNQ6308; PRO20933 |
| WB Predicted band size | 27 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与BDH2抗体相关的文献概览，供参考：
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1. **文献名称**: *BDH2 mediates ferroptosis via lipid peroxidation and iron metabolism*
**作者**: Li Y, et al.
**摘要**: 该研究揭示了BDH2通过调节铁死亡相关脂质过氧化和细胞内铁稳态的分子机制，实验中采用BDH2特异性抗体进行Western blot验证其在肝癌细胞中的表达变化。
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2. **文献名称**: *Role of BDH2 in Alzheimer's disease pathogenesis*
**作者**: Smith J, et al.
**摘要**: 文章利用BDH2抗体进行免疫组化分析，发现BDH2在阿尔茨海默病患者脑组织中表达异常，可能通过影响神经元铁代谢加剧淀粉样蛋白沉积。
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3. **文献名称**: *BDH2 modulates mitochondrial function and oxidative stress in cancer*
**作者**: Wang X, et al.
**摘要**: 研究通过siRNA敲低和BDH2抗体检测，证实BDH2通过调控线粒体功能影响结直肠癌细胞的氧化应激耐受性，为靶向治疗提供依据。
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**注**：以上文献为示例性内容，实际研究中建议通过PubMed或Web of Science检索具体文献。若需实验抗体信息，可参考抗体公司(如CST、Abcam)提供的技术文档及引用文献。
The BDH2 (3-hydroxybutyrate dehydrogenase 2) antibody is a tool used to study the BDH2 enzyme, a mitochondrial protein involved in ketone body metabolism and iron homeostasis. BDH2 catalyzes the oxidation of 3-hydroxybutyrate to acetoacetate, linking it to energy metabolism, particularly during fasting or metabolic stress. Additionally, BDH2 plays a critical role in regulating cellular iron levels by synthesizing the iron-binding molecule 2.5-dihydroxybenzoic acid (2.5-DHBA), which modulates iron export. Dysregulation of BDH2 has been implicated in iron-related disorders, neurodegenerative diseases, and cancer.
The BDH2 antibody is essential for detecting and quantifying BDH2 protein expression in tissues or cells via techniques like Western blotting, immunohistochemistry, or immunofluorescence. Researchers use it to investigate BDH2's role in metabolic pathways, iron metabolism, and diseases such as anemia, Alzheimer’s disease, or tumors. Specificity and validation of the antibody are crucial, as cross-reactivity with homologous enzymes (e.g., BDH1) may occur. Most BDH2 antibodies target epitopes within conserved regions of the protein, often raised in hosts like rabbits or mice. Understanding BDH2's function through antibody-based studies provides insights into therapeutic strategies targeting metabolic dysfunction or iron imbalance.
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