| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | HBP2; ARTC1; MDS001; HSPC339 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human BBX |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于BBX抗体的3篇参考文献示例(内容为虚构，仅供格式参考)：
1. **文献名称**：**《BBX蛋白在结直肠癌中的表达及功能研究》**
**作者**：Zhang L, Wang Y, Chen H
**摘要**：本研究通过制备特异性抗BBX蛋白的多克隆抗体，验证其在结直肠癌组织中的高表达。抗体经Western blot和免疫组化验证，结果显示BBX通过调控Wnt/β-catenin通路促进肿瘤侵袭，为潜在治疗靶点。
2. **文献名称**：**《拟南芥BBX家族基因光形态建成调控机制》**
**作者**：Kim S, Park J, Lee M
**摘要**：利用商业化BBX抗体分析拟南芥BBX蛋白在光信号通路中的作用。免疫共沉淀实验表明，BBX21与HY5互作，调控下游光响应基因，揭示其在植物光形态建成中的关键角色。
3. **文献名称**：**《新型抗BBX单克隆抗体的开发及其在肝癌诊断中的应用》**
**作者**：Li X, Liu R, Zhou W
**摘要**：报道一种高灵敏度的抗BBX单克隆抗体制备，通过ELISA和流式细胞术验证其特异性。临床样本分析显示，血清BBX水平与肝癌进展相关，提示其作为生物标志物的潜力。
(注：以上文献及作者为虚构示例，实际文献需通过学术数据库检索。)
BBX (B-box transcription factor) antibodies are essential tools for studying the functional roles of BBX proteins, a family of zinc-finger transcription factors involved in diverse biological processes. Initially identified in the early 2000s, BBX proteins are characterized by conserved B-box domains that mediate protein-protein interactions and regulate transcriptional activity. They play critical roles in cellular processes such as circadian rhythm regulation, photomorphogenesis in plants, and immune responses. In humans, BBX proteins (e.g., BBX1-8) are increasingly linked to cancer progression, neurodegenerative diseases, and inflammatory disorders. For instance, BBX overexpression has been observed in certain cancers, influencing tumor proliferation and metastasis via pathways like Wnt/β-catenin or NF-κB.
BBX antibodies enable researchers to detect and quantify BBX protein expression in tissues or cell lines, facilitating studies on its subcellular localization, interaction partners, and post-translational modifications. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Recent studies highlight BBX's dual roles as oncogenes or tumor suppressors, depending on cellular context, underscoring its therapeutic potential. Challenges remain in understanding isoform-specific functions and context-dependent regulatory mechanisms. Overall, BBX antibodies are pivotal in unraveling the molecular basis of BBX-related diseases and developing targeted therapies.
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