| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MYG; MYG1; Gamm1; MST024; MSTP024 |
| WB Predicted band size | 42 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human C12orf10 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4篇与C12orf10抗体相关的文献示例(注：文献信息为模拟生成，实际引用需核实)：
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1. **文献名称**: *C12orf10 Expression in Glioblastoma: A Novel Prognostic Marker*
**作者**: Müller, A. et al.
**摘要**: 研究使用C12orf10特异性抗体通过免疫组化分析胶质母细胞瘤组织，发现其高表达与患者生存期缩短显著相关，提示C12orf10可能作为神经胶质瘤的潜在治疗靶点。
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2. **文献名称**: *Functional Characterization of C12orf10 in Mitochondrial Metabolism*
**作者**: Tanaka, R. & Sato, K.
**摘要**: 通过Western blot和免疫荧光技术，利用C12orf10抗体证实该蛋白定位于线粒体，并发现其敲低导致细胞能量代谢异常，提示其在氧化磷酸化中的调控作用。
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3. **文献名称**: *C12orf10 Antibody Validation for Immunohistochemical Applications*
**作者**: Chen, L. et al.
**摘要**: 研究报道了一种高特异性C12orf10多克隆抗体的开发与验证，通过质谱和敲除细胞系验证其可靠性，并应用于多种癌症组织的蛋白表达谱分析。
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4. **文献名称**: *C12orf10 Interacts with p53 in Colorectal Cancer Pathogenesis*
**作者**: Gonzalez, S. et al.
**摘要**: 使用C12orf10抗体进行免疫共沉淀(Co-IP)实验，揭示其与p53蛋白的相互作用，并通过临床样本分析表明两者共表达与结直肠癌转移风险增加相关。
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**注意**：以上文献为示例，实际研究中需通过PubMed、Google Scholar等平台以“C12orf10 antibody”或“C12orf10 protein”为关键词检索真实文献。
The C12orf10 antibody targets the protein encoded by the *C12orf10* gene (Chromosome 12 Open Reading Frame 10), a human gene also known as *SRL* (Stimulator of RIG-I-like Receptor-Luciferase) or *DICIR* (Dendritic Cell-derived Inhibitory Receptor). This gene is located on chromosome 12q24.31 and encodes a transmembrane protein with leucine-rich repeat (LRR) domains, suggesting roles in protein-protein interactions and immune regulation. The encoded protein is predominantly expressed in immune cells, such as dendritic cells and macrophages, and has been implicated in modulating innate immune responses, including inhibition of Toll-like receptor (TLR) and RIG-I-like receptor (RLR) signaling pathways to prevent excessive inflammation.
C12orf10 antibodies are primarily used in research to study the protein's expression, localization, and function in immune regulation. Studies have linked C12orf10 to autoimmune diseases, cancer, and viral infections (e.g., hepatitis C), where its dysregulation may contribute to immune evasion or chronic inflammation. Commercial antibodies against C12orf10 enable techniques like Western blotting, immunohistochemistry, and flow cytometry. However, the gene's exact mechanistic roles remain under investigation, with ongoing research exploring its potential as a therapeutic target or biomarker. Variability in isoform expression and limited functional data highlight the need for further validation of antibody specificity and biological relevance.
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