| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | CAVII |
| WB Predicted band size | 30 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于CA7(碳酸酐酶VII)抗体的模拟参考文献示例(内容为虚构，供参考)：
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1. **文献名称**: "Immunohistochemical Analysis of Carbonic Anhydrase VII in Human Brain Tumors"
**作者**: Smith A, et al.
**摘要**: 本研究通过CA7特异性抗体检测了胶质瘤和脑膜瘤组织中CA7的表达，发现CA7在低级别胶质瘤中显著高表达，提示其可能作为神经胶质肿瘤分级的潜在标志物。
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2. **文献名称**: "CA7 Antibody Validation for Western Blot in Colorectal Cancer Tissues"
**作者**: Chen L, et al.
**摘要**: 文章验证了商业化CA7抗体在结直肠癌组织Western Blot中的特异性，并发现CA7蛋白水平与患者预后呈负相关，支持其在结直肠癌代谢研究中的应用价值。
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3. **文献名称**: "Role of Carbonic Anhydrase VII in Epilepsy: An Antibody-Based Proteomic Study"
**作者**: Rossi G, et al.
**摘要**: 利用CA7抗体进行脑组织免疫组化分析，发现癫痫患者海马区CA7表达下调，表明CA7可能通过调节pH稳态影响神经元兴奋性，为癫痫机制研究提供新方向。
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**备注**：以上文献为示例，实际引用请通过PubMed或Web of Science检索真实论文(关键词：Carbonic Anhydrase VII antibody, CA7 biomarker)。
CA7 (Carbonic Anhydrase VII) is a member of the carbonic anhydrase enzyme family, which catalyzes the reversible hydration of carbon dioxide to bicarbonate and protons. Primarily expressed in the brain, liver, and gastrointestinal tract, CA7 plays a critical role in pH regulation, ion transport, and metabolic processes. Its dysfunction has been implicated in neurological disorders, including epilepsy, due to its association with acid-base imbalances affecting neuronal excitability.
CA7 antibodies are immunological tools designed to detect and quantify the CA7 protein in research and diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and ELISA to study CA7 expression patterns, tissue localization, and potential roles in disease mechanisms. For example, studies have linked CA7 mutations to autosomal recessive cerebral calcification and epilepsy, highlighting its importance in neurological health. Additionally, CA7 antibodies aid in exploring its interaction with other proteins and regulatory pathways, offering insights into therapeutic targets.
Recent research also investigates CA7's involvement in cancer, as altered carbonic anhydrase activity may influence tumor microenvironment pH and metastasis. The development of CA7-specific antibodies has enhanced diagnostic precision, enabling the identification of CA7 as a biomarker in certain pathologies. Overall, CA7 antibodies serve as essential reagents for unraveling the enzyme's biological functions and clinical relevance across diverse physiological and pathological conditions.
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