Rabbit Polyclonal CHMP5 Antibody

CHMP5 (Charged Multivesicular Body Protein 5), a component of the ESCRT-III (Endosomal Sorting Complex Required for Transport III) complex, plays a critical role in membrane remodeling processes such as cytokinesis, viral budding, and multivesicular body formation. It facilitates the sorting of ubiquitinated cargoes into intralumenal vesicles and participates in membrane scission events. CHMP5 antibodies are tools used to detect, quantify, or inhibit this protein in research. These antibodies are widely employed in techniques like Western blotting, immunofluorescence, and immunoprecipitation to study CHMP5's localization, interactions, and regulatory mechanisms. Dysregulation of CHMP5 has been linked to diseases, including cancer, neurodegenerative disorders, and immunological conditions, due to its involvement in cell division and stress response pathways. Researchers also utilize CHMP5 antibodies to explore its role in viral pathogenesis, as many viruses hijack ESCRT machinery for release. Commercial CHMP5 antibodies are typically raised in rabbits or mice, validated for specificity against conserved epitopes. Recent studies highlight CHMP5's potential as a therapeutic target, driving demand for high-affinity antibodies to dissect its molecular functions and disease associations.