| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | Homeobox protein Hox-C9, Homeobox protein Hox-32, Hoxc9, Hox-32, Hoxc-9 |
| Entrez GeneID | 15427 |
| WB Predicted band size | 29.2kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | This Mouse Hoxc9 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 101-129 amino acids from the Central region of mouse Hoxc9. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
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以下是关于NUBP2抗体的3篇示例参考文献(内容为模拟虚构，仅供参考)：
1. **文献名称**：《NUBP2在结直肠癌中的异常表达及其临床意义》
**作者**：李明等
**摘要**：本研究通过免疫组化技术，利用NUBP2特异性抗体检测结直肠癌组织中NUBP2蛋白的表达水平，发现其高表达与肿瘤分期和患者不良预后显著相关，提示NUBP2可能作为潜在的癌症生物标志物。
2. **文献名称**：《NUBP2抗体在细胞铁硫簇组装中的功能验证》
**作者**：张华等
**摘要**：通过Western blot和免疫荧光技术，验证了NUBP2抗体在HeLa细胞中的特异性，证实NUBP2通过调控铁硫蛋白的合成影响线粒体功能，为相关代谢疾病研究提供工具支持。
3. **文献名称**：《NUBP2与卵巢癌化疗耐药性的关联研究》
**作者**：王磊等
**摘要**：采用NUBP2抗体进行蛋白质印迹分析，发现卵巢癌耐药细胞系中NUBP2表达上调，敲低NUBP2可增强顺铂敏感性，表明其参与化疗耐药机制。
4. **文献名称**：*NUBP2 knockdown inhibits tumor growth via cell cycle arrest in lung adenocarcinoma*
**作者**：Chen X et al.
**摘要**：通过siRNA和NUBP2抗体检测，证明抑制NUBP2可阻滞肺癌细胞G1/S期转化，并降低Cyclin D1表达，提示其作为治疗靶点的潜力。
(注：以上文献为示例性内容，实际引用请查询真实数据库。)
The NUBP2 (Nucleotide Binding Protein 2) antibody is a tool used to detect and study the NUBP2 protein, a member of the cytosolic iron-sulfur cluster assembly (CIA) machinery. NUBP2. also known as cytosolic Fe-S cluster assembly factor 2. plays a critical role in cellular iron-sulfur (Fe-S) cluster biogenesis, a conserved process essential for the function of numerous enzymes involved in DNA repair, metabolism, and redox regulation. It forms a heterotetrameric complex with its homolog NUBP1. facilitating the transfer of Fe-S clusters to target apoproteins. Dysregulation of NUBP2 has been implicated in various pathologies, including cancer, where its overexpression may promote tumor progression by sustaining proliferative signaling or genomic instability.
NUBP2 antibodies are widely utilized in research to investigate protein expression patterns, subcellular localization (predominantly cytoplasmic), and interactions via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies are critical for elucidating NUBP2's role in cellular homeostasis, stress responses, and disease mechanisms. Commercial NUBP2 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes, and require validation using knockout controls or siRNA-mediated silencing to ensure specificity. Ongoing studies explore its potential as a biomarker or therapeutic target, particularly in cancers with dysregulated Fe-S metabolism.
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