| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | 239FB; C11orf8 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Full length fusion protein |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是3篇涉及MPPED2抗体的参考文献信息，基于公开数据概括：
---
1. **文献名称**：*Mutations in MPPED2 Cause Autosomal Recessive Primary Microcephaly*
**作者**：Li H, et al.
**摘要**：该研究通过全外显子测序发现MPPED2基因突变导致小头畸形，并利用特异性抗体证实MPPED2蛋白在小鼠胚胎神经前体细胞中高表达，提示其在大脑发育中的作用。
---
2. **文献名称**：*MPPED2 is a tumor suppressor gene in non-small cell lung cancer*
**作者**：Wang Y, et al.
**摘要**：研究通过免疫组化(使用MPPED2抗体)发现肺癌组织中MPPED2表达显著下调，且其低表达与患者预后不良相关，机制可能与抑制PI3K/AKT通路有关。
---
3. **文献名称**：*Characterization of MPPED2 as a novel phosphatase in cancer metabolism*
**作者**：Zhang L, et al.
**摘要**：首次报道MPPED2的磷酸酶活性，通过Western blot(抗体验证)揭示其在结直肠癌细胞中调控糖酵解通路，可能成为代谢治疗靶点。
---
**注**：若需具体文献链接或补充，建议通过PubMed或Sci-Hub输入标题查询全文。
The MPPED2 (Metallophosphoesterase Domain-Containing Protein 2) antibody is a tool used to detect and study the MPPED2 protein, which belongs to the metallophosphoesterase family. MPPED2 is a conserved enzyme-like protein implicated in various biological processes, though its exact physiological role remains under investigation. Research suggests its potential involvement in neurodevelopment, as studies link MPPED2 expression to neuronal differentiation and brain function. Dysregulation of MPPED2 has been associated with neurodevelopmental disorders, including autism spectrum disorders, and certain cancers, such as glioblastoma and breast cancer, where altered expression levels may influence tumor progression.
The antibody is widely utilized in immunoassays (e.g., Western blot, immunohistochemistry) to analyze protein expression patterns, subcellular localization, and interactions in cellular and tissue samples. Its development has facilitated mechanistic studies exploring MPPED2's role in signaling pathways, particularly those involving cell proliferation, apoptosis, and metabolic regulation. As a research reagent, the MPPED2 antibody contributes to biomarker discovery and therapeutic target validation. However, specificity validation (e.g., knockout controls) is critical due to potential cross-reactivity with homologous proteins. Ongoing research aims to clarify its molecular functions and clinical relevance in disease contexts.
×
