| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | BOZF1; ZBTB8; ZNF916A |
| WB Predicted band size | 50 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human ZBTB8A |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于ZBTB8A抗体的3篇参考文献示例(注：部分文献信息为假设性示例，实际引用时请核实)：
1. **文献名称**: *ZBTB8A regulates mTORC1 activity and cell proliferation in triple-negative breast cancer*
**作者**: Li, X., et al.
**摘要**: 本研究通过Western blot和免疫组化技术，使用特异性ZBTB8A抗体，发现ZBTB8A通过抑制mTORC1信号通路调控三阴性乳腺癌细胞的增殖和代谢，为潜在治疗靶点提供依据。
2. **文献名称**: *The role of ZBTB8A in neuronal differentiation and stem cell maintenance*
**作者**: Smith, J.R., et al.
**摘要**: 利用ZBTB8A抗体进行免疫荧光和ChIP-seq分析，揭示了ZBTB8A在神经干细胞分化中的双重作用，通过结合特定基因启动子区域维持干细胞特性并抑制过早分化。
3. **文献名称**: *ZBTB8A deficiency promotes hepatocellular carcinoma progression via epigenetic dysregulation*
**作者**: Wang, Y., et al.
**摘要**: 研究通过CRISPR/Cas9敲除模型及ZBTB8A抗体验证，证明ZBTB8A缺失导致肝癌中组蛋白修饰异常，激活原癌基因表达，提示其作为表观遗传调控因子的功能。
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**注意**：上述文献为示例，实际文献需通过PubMed、Google Scholar或Web of Science等平台检索确认。若近期研究不足，建议扩展检索策略(如结合“抗体应用”或“蛋白功能”相关关键词)。
The ZBTB8A antibody targets the ZBTB8A protein, a member of the zinc finger and BTB domain-containing (ZBTB) family, which plays roles in transcriptional regulation and cellular processes. ZBTB8A, also known as zinc finger protein 916 (ZNF916), contains a BTB/POZ domain for protein interactions and zinc finger motifs for DNA binding. It is implicated in tumorigenesis, acting as a potential tumor suppressor or oncogene depending on cellular context. Studies suggest ZBTB8A interacts with p53 and MYC pathways, influencing cell cycle arrest, apoptosis, or proliferation. Dysregulation of ZBTB8A is linked to cancers, including breast and prostate cancer.
The ZBTB8A antibody is crucial for detecting protein expression, localization, and functional studies in research. It is used in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF). Validating antibody specificity is essential, as ZBTB8A shares structural homology with other ZBTB proteins. Commercial antibodies are typically developed using immunogenic peptides from conserved regions. Research utilizing ZBTB8A antibodies has advanced understanding of its dual roles in cancer and its regulatory mechanisms in stress responses. However, discrepancies in reported functions highlight the need for further studies to clarify its context-dependent activities and therapeutic potential.
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