| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MST017; HSPC028; MSTP017 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human BZW2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
+ +
以下是关于BZW2抗体的3篇参考文献示例，包含文献名称、作者及摘要内容概括：
---
1. **文献名称**：*BZW2 promotes tumor progression in triple-negative breast cancer via activation of the mTOR signaling pathway*
**作者**：Li Y, et al.
**摘要**：
本研究通过免疫组化(使用BZW2抗体)发现BZW2在三阴性乳腺癌组织中高表达，并证实其通过激活mTOR通路促进肿瘤增殖和转移。研究强调了BZW2作为潜在治疗靶点的价值。
---
2. **文献名称**：*Characterization of BZW2 as a novel regulator of ER stress in hepatocellular carcinoma*
**作者**：Wang X, et al.
**摘要**：
作者利用BZW2特异性抗体进行Western blot和免疫荧光实验，发现BZW2通过调控内质网应激反应影响肝癌细胞存活。研究为BZW2在肝癌耐药性中的作用提供了机制解释。
---
3. **文献名称**：*Development and validation of a polyclonal antibody against human BZW2 for functional studies*
**作者**：Zhang R, et al.
**摘要**：
该文献报道了一种针对人源BZW2蛋白的多克隆抗体的开发与验证。通过ELISA、免疫沉淀及组织染色实验，证实该抗体具有高特异性和灵敏度，适用于体外及体内BZW2表达分析。
---
**备注**：以上文献为示例性质，实际文献需通过PubMed、Web of Science等数据库检索。若需具体文章，建议使用关键词“BZW2 antibody”或“BZW2 function”进一步查询近年发表的论文。
The BZW2 (Basic Leucine Zipper and W2 Domains 2) antibody is a tool used to study the BZW2 protein, encoded by the *BZW2* gene. BZW2. also known as HSPC240. is a member of the bZIP family of transcription factors and is implicated in regulating cellular stress responses, protein synthesis, and cell proliferation. It interacts with the integrated stress response (ISR) pathway, particularly under conditions like nutrient deprivation or endoplasmic reticulum (ER) stress, where it modulates the activity of eukaryotic initiation factors (eIFs) to control mRNA translation.
Research highlights BZW2's role in cancer biology. Overexpression of BZW2 is observed in several cancers, including breast, liver, and glioblastoma, where it promotes tumor progression, metastasis, and therapy resistance by enhancing cell survival and adaptation to stress. The BZW2 antibody is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect protein expression levels, subcellular localization, and interactions in both normal and pathological tissues.
Studies utilizing this antibody have contributed to understanding BZW2's regulatory mechanisms, such as its crosstalk with mTOR and integrin signaling pathways. Its development and validation support ongoing investigations into BZW2 as a potential diagnostic marker or therapeutic target in stress-related diseases and oncology.
×
