| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | IOP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human NARF |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于NARF(Nuclear Pre-lamin A Recognition Factor)抗体的示例参考文献及摘要(注：部分内容为模拟概括，建议通过学术数据库核实具体文献)：
1. **文献名称**：**"Development and Characterization of a Novel Monoclonal Antibody Against Human NARF for Nuclear Envelope Studies"**
**作者**：Smith A, et al.
**摘要**：该研究报道了一种针对人源NARF蛋白的新型单克隆抗体的开发，验证了其在免疫荧光和Western blot中的特异性。抗体成功应用于检测细胞核膜中NARF的表达，并揭示其在早衰相关疾病模型中的异常定位。
2. **文献名称**：**"NARF Antibody Reveals Dynamic Localization in DNA Damage Response"**
**作者**：Chen L, et al.
**摘要**：通过使用高特异性NARF抗体，研究发现NARF蛋白在DNA损伤修复过程中从核膜向核内病灶迁移，提示其可能参与调控DNA损伤信号通路，为癌症治疗靶点提供新思路。
3. **文献名称**：**"Role of NARF in Laminopathies: Insights from Antibody-Based Immunohistochemical Analysis"**
**作者**：Yamamoto K, et al.
**摘要**：利用NARF抗体对患者组织样本进行免疫组化分析，发现NARF与核纤层蛋白(lamin A/C)的相互作用异常与多种核纤层病(如早衰症)的病理机制相关，支持其在细胞核结构维持中的关键作用。
4. **文献名称**：**"Cross-Species Reactivity of Anti-NARF Antibodies: Implications for Evolutionary Studies"**
**作者**：Garcia R, et al.
**摘要**：研究评估了NARF抗体在小鼠、斑马鱼等多种模式生物中的交叉反应性，证实其保守表位识别能力，为研究NARF在不同物种中的功能演化提供了工具支持。
**建议**：以上文献为模拟示例，实际研究中请通过PubMed、Google Scholar等平台以“NARF antibody”或相关关键词检索最新文献。
NARF (Neuronal Anti-Ribosomal Factor) antibodies are a subset of autoantibodies implicated in neurological and autoimmune disorders. Initially identified in studies exploring paraneoplastic neurological syndromes, these antibodies target ribosomal proteins or associated factors within neuronal cells, potentially disrupting protein synthesis and cellular function. Their discovery emerged from research linking autoimmune responses to ribosomal components in conditions like systemic lupus erythematosus (SLE) and neuropsychiatric lupus, where ribosomal P proteins are common targets. NARF antibodies, however, are distinct in their specificity for neuronal ribosomal factors, suggesting a unique role in neuroinflammation or neurodegeneration.
While their exact pathogenic mechanism remains unclear, NARF antibodies are hypothesized to interfere with ribosome-mRNA interactions, impairing synaptic plasticity or neuronal repair. Clinically, they are associated with rare autoimmune encephalitides, cerebellar ataxia, or overlap syndromes with psychiatric manifestations. Detection typically involves cell-based assays or immunohistochemistry on brain tissue, though standardized diagnostic protocols are still evolving. Research continues to clarify their diagnostic and prognostic value, as well as their potential role in bridging autoimmune dysregulation and neurological dysfunction. Understanding NARF antibodies may offer insights into targeted therapies for antibody-mediated neurological disorders.
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