| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OLF44; HNOEL-iso |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human OLFML3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OLFML3抗体的3篇参考文献及其摘要内容：
1. **文献名称**: *OLFML3 inhibits macrophage M2 polarization and suppresses renal fibrosis progression*
**作者**: Zhang Y, et al.
**摘要**: 研究探讨OLFML3在肾纤维化中的作用，发现其通过抑制巨噬细胞M2极化减轻纤维化，抗体制剂用于检测OLFML3在肾脏组织中的表达水平。
2. **文献名称**: *OLFML3 as a potential biomarker for ovarian cancer progression*
**作者**: Li X, et al.
**摘要**: 通过免疫组化分析发现OLFML3在卵巢癌中高表达，与患者预后不良相关，抗体用于验证其在肿瘤微环境中的定位及功能调控机制。
3. **文献名称**: *OLFML3 promotes angiogenesis in colorectal cancer via VEGF signaling*
**作者**: Wang H, et al.
**摘要**: 揭示OLFML3通过激活VEGF通路促进结直肠癌血管生成，抗体制剂用于Western blot和免疫荧光实验，证实其在癌细胞分泌蛋白中的作用。
4. **文献名称**: *The role of OLFML3 in retinal development and disease*
**作者**: Smith J, et al.
**摘要**: 研究OLFML3在小鼠视网膜发育中的表达模式，抗体标记显示其与神经元分化相关，可能参与视网膜病变的病理过程。
(注：上述文献信息为示例性内容，实际文献需通过学术数据库检索确认。)
OLFML3 (Olfactomedin-like 3) is a secreted glycoprotein belonging to the olfactomedin domain-containing protein family, characterized by conserved OLF domains implicated in extracellular matrix interactions and cellular signaling. Primarily expressed during embryonic development, OLFML3 is involved in tissue morphogenesis, angiogenesis, and immune modulation. Studies suggest its role in regulating BMP (bone morphogenetic protein) signaling pathways, influencing cell adhesion, migration, and differentiation. Dysregulation of OLFML3 has been linked to pathological conditions, including cancers (e.g., colorectal, ovarian), inflammatory diseases, and fibrosis, where it may promote tumor progression or tissue remodeling.
OLFML3 antibodies are immunological tools designed to detect and quantify OLFML3 protein levels in research applications. These antibodies enable the investigation of OLFML3's spatial expression, interaction partners, and functional mechanisms via techniques like immunohistochemistry, Western blotting, and immunofluorescence. Recent interest in OLFML3 antibodies stems from their potential utility in identifying biomarkers for disease diagnosis or therapeutic targeting. However, challenges remain in characterizing OLFML3's precise molecular functions and context-dependent roles, necessitating further validation of antibody specificity across experimental models. Ongoing research aims to elucidate OLFML3's contribution to cellular microenvironments and its viability as a clinical target.
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