| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DOC45; GBP45; GTBP9; GTPBP9; PTD004 |
| WB Predicted band size | 45 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human OLA1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于OLA1抗体的参考文献示例，供参考(注：以下为模拟示例，实际文献请通过学术数据库查询)：
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1. **文献名称**: *OLA1 Mediates Oxidative Stress Response and Regulates Cell Survival in Breast Cancer*
**作者**: Li, X., et al.
**摘要**: 研究使用OLA1抗体分析乳腺癌细胞系和组织样本，发现OLA1通过调控ROS水平影响细胞存活，高表达OLA1与化疗耐药性相关。
2. **文献名称**: *Characterization of a Novel Monoclonal Antibody Against OLA1 for Detecting Its Role in Neurodegeneration*
**作者**: Müller, R., et al.
**摘要**: 开发针对OLA1的单克隆抗体，验证其在阿尔茨海默病模型中的特异性，发现OLA1异常聚集与tau蛋白病理相关。
3. **文献名称**: *OLA1 Deficiency Attenuates Hepatic Fibrosis via Modulating TGF-β/Smad Signaling*
**作者**: Wang, T., et al.
**摘要**: 通过OLA1抗体检测肝纤维化模型，证明OLA1缺失抑制TGF-β通路活性，减缓纤维化进程，提示其作为治疗靶点潜力。
4. **文献名称**: *OLA1 Antibody-Based ELISA for Early Diagnosis of Pancreatic Cancer*
**作者**: Gupta, S., et al.
**摘要**: 建立基于OLA1抗体的血液检测方法，发现血清OLA1水平在胰腺癌早期显著升高，可能成为新型生物标志物。
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**建议**：如需真实文献，请访问PubMed(https://pubmed.ncbi.nlm.nih.gov)或Google Scholar，搜索关键词“OLA1 antibody”、“OLA1 function”或结合具体研究领域(如“OLA1 cancer”)。
The OLA1 (Obg-like ATPase 1) antibody is a tool used to study the OLA1 protein, a conserved member of the YchF subfamily of GTPases involved in cellular stress response and translational regulation. OLA1. encoded by the *OLA1* gene in humans, plays dual roles in ATP/GTP hydrolysis and interacts with critical cellular components like stress granules, ribosomes, and translation factors. It modulates protein synthesis under stress conditions, influences cell proliferation, apoptosis, and oxidative stress adaptation, and has been implicated in diseases such as cancer and neurodegenerative disorders.
Antibodies targeting OLA1 enable researchers to investigate its expression, localization, and function through techniques like Western blotting, immunofluorescence, and immunohistochemistry. These antibodies are essential for identifying OLA1's role in pathways like mTOR and AMPK signaling, as well as its potential as a biomarker in tumors, where its expression often correlates with prognosis. Available as monoclonal or polyclonal variants, OLA1 antibodies are validated for specificity across human and model organisms, aiding mechanistic studies in cellular stress responses and disease pathogenesis. Their applications span basic research, drug discovery, and diagnostic development.
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