| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ARAT; HMFN1045; GS1999FULL |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human DGAT2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于DGAT2抗体的3篇参考文献示例(内容为虚构，仅供参考格式)：
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1. **文献名称**: "DGAT2-mediated lipid droplet formation in hepatic steatosis"
**作者**: Smith A, et al.
**摘要**: 本研究通过Western blot和免疫荧光技术，利用特异性DGAT2抗体探究了DGAT2在非酒精性脂肪肝中的表达及功能。结果显示，DGAT2蛋白水平在脂肪肝模型中显著升高，抑制DGAT2可减少肝脏脂质积累。
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2. **文献名称**: "Tissue-specific expression of DGAT2 in mammals"
**作者**: Chen B, et al.
**摘要**: 通过比较不同组织的DGAT2蛋白表达，作者使用DGAT2抗体进行免疫组化分析，发现其在肝脏和脂肪组织高表达，且高脂饮食可诱导其表达上调，提示其在脂代谢中的组织特异性调控作用。
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3. **文献名称**: "Role of DGAT2 in cancer cell lipid metabolism"
**作者**: Wang C, et al.
**摘要**: 本研究结合siRNA敲降和DGAT2抗体检测，揭示DGAT2在癌细胞中通过调控甘油三酯合成促进肿瘤生长，抗体阻断实验进一步验证其作为潜在治疗靶点的可能性。
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*注：以上为模拟内容，实际文献需通过PubMed/Google Scholar等平台检索关键词“DGAT2 antibody”或“DGAT2 inhibitor”获取。建议引用时补充真实文献的DOI或期刊信息。*
DGAT2 (diacylglycerol O-acyltransferase 2) is a key enzyme in lipid metabolism, primarily responsible for catalyzing the final step of triglyceride synthesis by transferring a fatty acyl group from acyl-CoA to diacylglycerol. Unlike its isoform DGAT1. DGAT2 is embedded in the endoplasmic reticulum membrane and exhibits tissue-specific expression, with high activity in the liver, adipose tissue, and mammary glands. Its role in lipid storage and lipoprotein assembly makes it a critical target for studying metabolic disorders, including obesity, non-alcoholic fatty liver disease (NAFLᴅ), and type 2 diabetes. Dysregulation of DGAT2 has also been linked to cancer progression, as lipid droplets contribute to tumor cell survival under stress.
DGAT2 antibodies are essential tools for detecting and quantifying DGAT2 protein levels in research. These antibodies enable the investigation of DGAT2's expression patterns, subcellular localization, and regulatory mechanisms through techniques like Western blotting, immunohistochemistry, and immunofluorescence. High-specificity DGAT2 antibodies help distinguish it from DGAT1. minimizing cross-reactivity. Researchers use these antibodies to explore DGAT2's functional roles in metabolic pathways, evaluate its therapeutic potential in lipid-related diseases, and validate genetic or pharmacological interventions in preclinical models. Commercial DGAT2 antibodies are typically developed in rabbits or mice, with validation in human, mouse, or rat samples, ensuring broad applicability in translational studies.
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