| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human ZNF707 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇关于ZNF707抗体的假设性参考文献示例(注：文献内容为虚构，仅供示例参考)：
1. **文献名称**：*ZNF707 Antibody Validation in Epigenetic Regulation Studies*
**作者**：Chen L, et al.
**摘要**：本研究验证了ZNF707抗体的特异性，证实其在人细胞系中可有效检测内源性ZNF707蛋白。通过CRISPR敲除和免疫印迹实验，发现ZNF707通过与DNA甲基转移酶DNMT3A互作，参与胚胎干细胞的表观遗传调控。
2. **文献名称**：*ZNF707 Expression in Breast Cancer: Prognostic Implications*
**作者**：Wang Y, et al.
**摘要**：利用ZNF707抗体对乳腺癌组织进行免疫组化分析，发现ZNF707低表达与患者不良预后相关。机制研究表明，ZNF707通过抑制癌基因MYC的转录活性发挥抑癌作用。
3. **文献名称**：*Functional Analysis of ZNF707 in DNA Damage Repair*
**作者**：Smith J, et al.
**摘要**：通过ZNF707抗体进行染色质免疫沉淀(ChIP)，揭示ZNF707在DNA双链断裂修复中招募HDAC1复合物，调控组蛋白去乙酰化，影响同源重组修复效率。
4. **文献名称**：*ZNF707 Knockout Mice Reveal Embryonic Developmental Defects*
**作者**：Tanaka K, et al.
**摘要**：使用ZNF707抗体验证基因敲除小鼠模型，发现ZNF707缺失导致胚胎期神经管闭合异常，提示其在神经发育中通过调控Wnt信号通路发挥作用。
(注：以上文献为虚构示例，实际研究中请通过PubMed或专业数据库检索真实文献。)
The ZNF707 antibody is a tool used to study the ZNF707 protein, a member of the zinc finger protein (ZFP) family characterized by conserved C2H2-type zinc finger domains. These proteins typically function as transcription regulators by binding DNA or interacting with chromatin-modifying complexes. ZNF707 is implicated in epigenetic regulation, potentially influencing gene expression during development, cellular differentiation, or disease. Studies suggest it may interact with Polycomb repressive complexes (PRCs) or NuRD complexes, which are critical for maintaining chromatin states and silencing specific genes. Dysregulation of ZNF707 has been tentatively linked to cancer and neurodevelopmental disorders, though its precise biological roles remain under investigation.
The ZNF707 antibody is commonly generated in hosts like rabbits or mice using immunogenic peptides or recombinant protein fragments. It enables researchers to detect ZNF707 expression in various applications, including Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and chromatin immunoprecipitation (ChIP). Validation often involves knockout cell lines or tissues to confirm specificity. Commercial antibodies typically provide data on reactivity (human, mouse, rat), clonality (monoclonal/polyclonal), and conjugate options (e.g., HRP, FITC). As research progresses, this antibody serves as a key reagent for elucidating ZNF707's role in gene regulation networks and disease mechanisms.
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