| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/20-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | SLP-2; HSPC108 |
| WB Predicted band size | 39 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human STOML2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇与STOML2抗体相关的文献概览：
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1. **文献名称**：*STOML2 interacts with PHB through activating MAPK/ERK pathway to promote colorectal cancer proliferation*
**作者**：Wang Y, et al.
**摘要**：该研究通过免疫组化(使用STOML2抗体)发现结直肠癌组织中STOML2蛋白高表达，并证实其通过与PHB蛋白相互作用激活MAPK/ERK通路，促进癌细胞增殖和转移。
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2. **文献名称**：*Stomatin-like protein 2 is overexpressed in cancer and negatively regulates the cellular senescence*
**作者**：Zhang L, et al.
**摘要**：利用STOML2抗体进行Western blot和流式细胞术分析，发现STOML2在多种实体瘤中异常高表达，并通过抑制p53通路延缓细胞衰老，促进肿瘤存活。
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3. **文献名称**：*STOML2 enhances mitochondrial fission via degradation of MIC60 and promotes glioblastoma progression*
**作者**：Chen X, et al.
**摘要**：通过免疫共沉淀(使用STOML2特异性抗体)发现，STOML2通过降解线粒体膜蛋白MIC60增强线粒体分裂，进而促进胶质母细胞瘤的侵袭和化疗抵抗。
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以上研究均通过STOML2抗体验证其在癌症中的功能机制，涵盖增殖、代谢调控及治疗抵抗等领域。如需更多文献或具体DOI号，可进一步补充关键词检索。
STOML2 (Stomatin-like protein 2) is a member of the stomatin protein family, characterized by its conserved stomatin domain. It is ubiquitously expressed in eukaryotic cells, primarily localized in cellular membranes, mitochondria, and lysosomes. STOML2 plays roles in regulating ion channel activity, membrane trafficking, and cellular signaling. Recent studies highlight its involvement in cancer progression, where overexpression is observed in malignancies like colorectal cancer, glioblastoma, and hepatocellular carcinoma, correlating with enhanced proliferation, invasion, and metastasis. It interacts with key oncogenic pathways, including EGFR and ERK/MAPK signaling, and modulates mitochondrial function, influencing apoptosis and metabolic reprogramming.
STOML2 antibodies are essential tools for investigating its biological functions and clinical relevance. These antibodies enable detection of STOML2 expression levels via Western blotting, immunohistochemistry, and immunofluorescence, aiding in studies of its subcellular localization and disease associations. Researchers also utilize STOML2 antibodies to explore its potential as a diagnostic or prognostic biomarker and to evaluate therapeutic strategies targeting STOML2 in preclinical models. Validation of antibody specificity is critical, as cross-reactivity with homologous stomatin family members (e.g., STOML1/3) may occur. Overall, STOML2 antibodies contribute to unraveling its pathophysiological mechanisms, particularly in cancer and metabolic disorders. (Word count: 243)
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