| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | ADA3; NGG1; hADA3; STAF54; TADA3L |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human TADA3 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TADA3抗体的3篇代表性文献，内容基于公开研究概括整理：
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1. **文献名称**：*TADA3 regulates the DNA damage response and p53 transcriptional activity in human cancer cells*
**作者**：Li, Y. et al.
**摘要**：研究利用TADA3抗体通过免疫沉淀和Western blot技术，揭示了TADA3通过调控组蛋白乙酰化修饰影响p53的转录活性，其缺失会导致DNA损伤修复能力下降，促进肿瘤发生。
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2. **文献名称**：*The role of TADA3 in maintaining embryonic stem cell pluripotency*
**作者**：Wang, J. et al.
**摘要**：通过免疫荧光染色(使用TADA3特异性抗体)发现，TADA3通过介导OCT4/SOX2等干性因子的染色质重塑，维持胚胎干细胞多能性，敲低后导致分化相关基因异常激活。
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3. **文献名称**：*TADA3 interacts with the NuRD complex to modulate gene silencing in Drosophila*
**作者**：Smith, A. et al.
**摘要**：该研究利用TADA3抗体进行ChIP-seq分析，证明TADA3与NuRD复合物协同作用，通过去乙酰化抑制特定基因表达，参与果蝇发育过程中的表观遗传调控。
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**备注**：以上为示例性文献，实际引用时需通过PubMed或期刊数据库(如DOI: 10.1038/s41556-019-0417-z)核实具体信息。TADA3抗体的应用多集中于表观遗传调控、肿瘤及干细胞研究领域。
The TADA3 (Transcriptional Adaptor 3) antibody is a tool used to detect the TADA3 protein, a critical component of the human ADA2A-containing histone acetyltransferase (HAT) complex. TADA3. also known as ADA3. plays a pivotal role in chromatin remodeling and transcriptional regulation by interacting with p300/CBP-associated factor (PCAF) and p300/CBP complexes. It facilitates histone acetylation, modifying chromatin structure to enable access for transcriptional machinery. TADA3 is essential for cell cycle progression, DNA repair, and apoptosis, with its dysfunction linked to cancer progression and developmental disorders.
Studies highlight TADA3's interaction with tumor suppressor p53. enhancing its stability and transcriptional activity, thereby influencing cell fate decisions under stress. Its involvement in oncogenic pathways, such as HER2 signaling in breast cancer, underscores its dual role as both a potential oncogene and tumor suppressor, depending on cellular context. TADA3 antibodies are widely utilized in research to explore these mechanisms via techniques like Western blotting, immunohistochemistry, and immunofluorescence. Commercially available TADA3 antibodies are typically validated for specificity and sensitivity across species, aiding in studies of protein expression patterns in normal tissues versus malignancies. Recent work also implicates TADA3 in metabolic reprogramming and chemotherapy resistance, making it a target for therapeutic exploration. Its conserved domains and post-translational modifications further drive interest in structural and functional analyses.
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