Rabbit Polyclonal RMND5B Antibody

RMND5B (Required for Meiotic Nuclear Division 5 Homolog B) is a protein encoded by the RMND5B gene, primarily localized in mitochondria. It belongs to the RING finger protein family and is implicated in mitochondrial protein quality control, ubiquitination processes, and regulation of mitochondrial dynamics. RMND5B antibodies are essential tools for studying its expression, localization, and molecular interactions in cellular and disease contexts. These antibodies are commonly used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to detect RMND5B in human, mouse, or rat samples. Research suggests RMND5B plays roles in mitophagy, respiratory chain complex assembly, and cellular stress responses, with potential links to cancer, neurodegenerative disorders, and mitochondrial diseases. Its involvement in ubiquitin-proteasome pathways highlights its importance in maintaining mitochondrial integrity. RMND5B antibodies help investigate its functional mechanisms, such as interactions with E3 ubiquitin ligase complexes or substrates, and its dysregulation in pathological conditions. Commercial RMND5B antibodies are typically validated for specificity using knockout cell lines or siRNA knockdown. Recent studies also explore its role in metabolic reprogramming and apoptosis, making it a target for therapeutic research. Proper validation and optimization of these antibodies are critical for reliable experimental outcomes in mitochondrial biology and disease-related studies.