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Rabbit Polyclonal INPP1 Antibody

  • 中文名: INPP1抗体
  • 别    名: nan
货号: IPDX09700
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/40-1/200 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

WB Predicted band size44 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenFusion protein of human INPP1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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参考文献

以下是关于INPP1抗体的模拟参考文献示例(注:文献为虚构示例,仅供参考):

1. **文献名称**:*Development and Characterization of a Monoclonal Antibody Targeting Human INPP1 for Metabolic Studies*

**作者**:Smith A, et al.

**摘要**:本研究开发了一种高特异性抗人INPP1的单克隆抗体,并通过Western blot和免疫荧光验证其在细胞系和组织样本中的应用,证实其在代谢调控研究中的可靠性。

2. **文献名称**:*INPP1 Knockdown Alters Inositol Phosphate Signaling: Insights from Antibody-Based Protein Localization*

**作者**:Chen L, et al.

**摘要**:利用INPP1特异性抗体进行亚细胞定位分析,发现INPP1主要分布于细胞质,其缺失导致肌醇磷酸代谢异常,影响细胞增殖和凋亡通路。

3. **文献名称**:*Role of INPP1 in Neurological Disorders: Immunohistochemical Evidence from Post-Mortem Brain Tissues*

**作者**:Rodriguez M, et al.

**摘要**:通过免疫组化技术结合INPP1抗体,分析阿尔茨海默病患者脑组织,发现INPP1表达水平与病理蛋白沉积呈负相关,提示其潜在神经保护作用。

4. **文献名称**:*Cross-Species Reactivity Validation of Commercial INPP1 Antibodies in Model Organisms*

**作者**:Tanaka K, et al.

**摘要**:评估多种商业INPP1抗体在小鼠、斑马鱼等模式生物中的交叉反应性,为跨物种研究提供实验依据,并推荐适用抗体型号。

(注:以上文献为假设性示例,实际引用需查询PubMed、Google Scholar等数据库获取真实研究。)

背景信息

The INPP1 (Inositol Polyphosphate-1-Phosphatase) antibody is a research tool designed to detect and study the INPP1 enzyme, which plays a critical role in regulating inositol phosphate metabolism. INPP1 catalyzes the hydrolysis of the 1-position phosphate from inositol 1.4.5-trisphosphate (Ins(1.4.5)P3) and inositol 1.3.4.5-tetrakisphosphate (Ins(1.3.4.5)P4), producing inositol 4.5-bisphosphate (Ins(4.5)P2) and inositol 3.4.5-trisphosphate (Ins(3.4.5)P3), respectively. This enzymatic activity influences cellular signaling pathways, including calcium mobilization, vesicle trafficking, and gene expression. INPP1 antibodies are widely used in Western blotting, immunohistochemistry, and immunofluorescence to investigate protein expression levels, subcellular localization, and tissue distribution. Researchers employ these antibodies to explore INPP1's involvement in diseases such as cancer, neurological disorders, and metabolic syndromes, where inositol phosphate dysregulation has been implicated. Recent studies also highlight its potential role in modulating insulin signaling and apoptosis. Commercial INPP1 antibodies are typically raised against specific epitopes, often validated for cross-reactivity in human, mouse, or rat models. Proper controls, such as knockout validation or peptide blocking, are essential to ensure specificity in experimental applications.

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