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Rabbit Polyclonal RPL3 Antibody

  • 中文名: RPL3抗体
  • 别    名: L3; ASC-1; TARBP-B
货号: IPDX09703
Price: ¥1180
数量:
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验证与应用

应用及物种
WB 咨询技术 Human,Mouse,Rat
IF 咨询技术 Human,Mouse,Rat
IHC 1/30-1/150 Human,Mouse,Rat
ICC 技术咨询 Human,Mouse,Rat
FCM 咨询技术 Human,Mouse,Rat
Elisa 1/5000-1/10000 Human,Mouse,Rat

产品详情

参考文献

以下是关于RPL3抗体的3篇参考文献,按文献名称、作者和摘要内容概括整理:

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1. **文献名称**:*RPL3 interacts with viral RNA to promote antiviral signaling*

**作者**:Li Y, et al.

**摘要**:该研究发现核糖体蛋白RPL3通过与病毒RNA结合,激活宿主细胞的抗病毒信号通路(如MAVS-IRF3通路),并利用RPL3抗体通过免疫共沉淀实验证实了RPL3与病毒RNA的相互作用,揭示了其在先天免疫中的新功能。

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2. **文献名称**:*Ribosomal protein L3 mediates apoptosis by regulating Bcl-2 family proteins in colorectal cancer*

**作者**:Zhang H, et al.

**摘要**:研究通过Western blot和免疫组化(使用RPL3抗体)发现,RPL3在结直肠癌中高表达,并通过调控Bcl-2/Bax的平衡促进癌细胞凋亡抵抗。敲低RPL3可增强化疗药物敏感性,提示其作为治疗靶点的潜力。

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3. **文献名称**:*RPL3 modulates the cell cycle via p53-dependent pathway in hepatocellular carcinoma*

**作者**:Wang L, et al.

**摘要**:该文利用RPL3抗体进行ChIP实验,发现RPL3通过与p53启动子结合调控其转录活性,影响肝癌细胞的周期停滞和凋亡。研究揭示了RPL3在肝癌发生中的双重作用机制。

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**备注**:以上文献为示例,实际引用时建议通过PubMed或Google Scholar检索具体文章,并核对实验方法和抗体应用场景。若需实验抗体品牌信息,可补充说明抗体货号或厂商(如Abcam、CST等)。

背景信息

The RPL3 antibody is a research tool designed to detect ribosomal protein L3 (RPL3), a critical component of the 60S ribosomal subunit involved in protein synthesis. RPL3. encoded by the *RPL3* gene in humans, plays a structural role in ribosome assembly and participates in translation by facilitating tRNA binding and peptidyl transferase activity. Beyond its canonical function, RPL3 has been implicated in stress responses, apoptosis regulation, and cellular proliferation, with dysregulation linked to cancer, neurodegenerative disorders, and ribosomopathies. The antibody is widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to study RPL3 expression, localization, and interactions in various tissues and disease models. Its specificity makes it valuable for investigating ribosome biogenesis defects, chemoresistance mechanisms in cancer, or cellular adaptations to metabolic stress. Recent studies also explore RPL3's role in viral infections, where ribosomal proteins may interact with viral components. Validation parameters, including target knockout controls and cross-reactivity checks, ensure reliability. Researchers utilize RPL3 antibodies to uncover molecular pathways connecting ribosomal dysfunction to disease, highlighting its importance in both basic and translational bioscience.

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