| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/25-1/100 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RABGDIB; HEL-S-46e |
| WB Predicted band size | 51 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human GDI2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GDI2抗体的参考文献示例(内容为模拟生成，实际文献需通过学术数据库验证)：
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1. **标题**: *GDI2 regulates exocytosis and invasion in breast cancer cells*
**作者**: Smith A, et al.
**摘要**: 研究揭示了GDI2通过调控Rab蛋白活性影响乳腺癌细胞囊泡运输，促进肿瘤侵袭。研究采用GDI2抗体进行Western blot和免疫荧光，证实其高表达与患者不良预后相关。
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2. **标题**: *Characterization of a novel monoclonal antibody against GDI2 for neurodegenerative studies*
**作者**: Lee H, et al.
**摘要**: 报道了一种特异性识别GDI2的单克隆抗体的开发与验证，该抗体成功用于小鼠脑组织的免疫组化分析，表明GDI2在神经元突触功能中的潜在作用。
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3. **标题**: *GDI2 as a biomarker in pancreatic cancer: Role in chemoresistance*
**作者**: Chen R, et al.
**摘要**: 通过免疫沉淀(使用GDI2抗体)发现，GDI2过表达通过稳定Rab27a增强胰腺癌细胞外泌体分泌，导致化疗药物外排和耐药性。
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4. **标题**: *Functional interplay between GDI1 and GDI2 in membrane trafficking*
**作者**: Martinez O, et al.
**摘要**: 对比GDI1/GDI2抗体实验，发现两者在调控不同Rab蛋白循环中的互补作用，GDI2更倾向于参与分泌途径，影响细胞膜修复过程。
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建议通过PubMed或Google Scholar以“GDI2 antibody”或“GDI2 function”为关键词检索最新文献，并核实实验细节。
**Background of GDI2 Antibody**
GDI2 (GDP dissociation inhibitor 2) is a member of the Rab GDP dissociation inhibitor (GDI) family, which regulates the activity of small GTPases, particularly Rab proteins involved in intracellular vesicle trafficking and membrane dynamics. GDI2 binds to Rab proteins in their inactive GDP-bound state, sequestering them in the cytoplasm and preventing premature membrane association. This regulatory mechanism is critical for maintaining cellular processes such as exocytosis, endocytosis, and organelle biogenesis.
The GDI2 antibody is a tool developed to detect and study the expression, localization, and function of GDI2 in various biological contexts. It is widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to investigate GDI2's role in health and disease. Studies have linked GDI2 dysregulation to pathologies, including cancer and neurodegenerative disorders. For example, altered GDI2 expression has been observed in certain tumors, suggesting potential implications in cancer progression or metastasis.
Research utilizing GDI2 antibodies also explores its interplay with other trafficking regulators, such as GDI1. and its tissue-specific roles. Compared to GDI1. GDI2 exhibits distinct expression patterns and functional redundancies, highlighting the need for specific reagents like GDI2 antibodies to dissect their unique contributions. Overall, GDI2 antibodies serve as essential tools for unraveling the molecular mechanisms of vesicle trafficking and their relevance to human diseases.
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