| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/30-1/150 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | GASP2 |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human GPRASP2 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于GPRASP2抗体的模拟参考文献示例(基于领域知识推测，实际文献需通过学术数据库验证)：
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1. **标题**: *GPRASP2 regulates G protein-coupled receptor sorting and degradation through endosomal pathways*
**作者**: Smith J, et al.
**摘要**: 本研究利用特异性GPRASP2抗体，揭示了其在GPCR内吞和溶酶体降解中的关键作用。通过免疫荧光和Western blot，发现GPRASP2与β-arrestin协同调控受体稳定性，影响下游信号传导。
2. **标题**: *Characterization of a novel polyclonal antibody for GPRASP2 in neuronal tissue analysis*
**作者**: Lee H, et al.
**摘要**: 文章报道了一种新型兔源多克隆抗体的开发与验证，该抗体可特异性识别GPRASP2蛋白。实验表明其在脑组织中的高表达，并提示其与神经退行性疾病相关蛋白存在潜在相互作用。
3. **标题**: *The role of GPRASP family proteins in cancer metastasis: Insights from antibody-based profiling*
**作者**: Zhang Y, et al.
**摘要**: 通过GPRASP2抗体分析多种癌细胞系，研究发现其表达水平与肿瘤迁移能力负相关，提示GPRASP2可能通过调控趋化因子受体CXCR4的膜定位抑制转移。
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**说明**：以上为推测性示例，真实文献需通过PubMed、Google Scholar等平台检索。建议使用关键词“GPRASP2 antibody”或“GPRASP2 function”查找最新研究。
The GPRASP2 (G Protein-Coupled Receptor Associated Sorting Protein 2) antibody is a tool used to study the function and expression of GPRASP2. a protein involved in the regulation of G protein-coupled receptor (GPCR) trafficking and degradation. GPRASP2 belongs to the GPRASP family, which plays a critical role in sorting GPCRs to lysosomes, thereby modulating receptor signaling and homeostasis. This protein is particularly implicated in the desensitization and internalization of certain GPCRs, including dopamine and opioid receptors, influencing processes like neurotransmitter signaling and cellular response pathways.
Antibodies targeting GPRASP2 enable researchers to investigate its expression patterns, subcellular localization, and interactions with GPCRs or other regulatory proteins. These antibodies are commonly utilized in techniques such as Western blotting, immunohistochemistry, and immunoprecipitation. Studies involving GPRASP2 antibodies have shed light on its potential roles in neurological disorders, addiction mechanisms, and cancer, where GPCR dysregulation is often observed.
The development and validation of GPRASP2 antibodies typically involve specificity tests using knockout cell lines or tissues to ensure minimal cross-reactivity with related family members like GPRASP1. As GPCR signaling pathways are therapeutic targets for numerous diseases, understanding GPRASP2's function through antibody-based research contributes to unraveling its pathophysiological relevance and potential as a drug target. Commercial availability of these antibodies facilitates broader exploration in both basic and translational research contexts.
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