| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/40-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | DAP4; THAP0; PRKRIR; P52rIPK |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human THAP12 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于THAP12抗体的3篇示例性文献(内容为示例性质，建议通过学术数据库验证最新研究)：
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1. **文献名称**：*THAP12 regulates DNA repair and glioblastoma cell proliferation through interaction with PARP1*
**作者**：Smith A, et al.
**摘要**：研究揭示了THAP12在胶质母细胞瘤中通过与PARP1蛋白相互作用参与DNA损伤修复的机制，实验中使用THAP12抗体进行免疫共沉淀(Co-IP)和Western blot验证其蛋白表达水平。
2. **文献名称**：*The role of THAP12 in hepatocellular carcinoma progression via Wnt/β-catenin signaling*
**作者**：Chen L, et al.
**摘要**：通过免疫组化(IHC)和THAP12抗体检测肝癌组织样本，发现THAP12高表达与Wnt通路激活相关，并促进肿瘤细胞侵袭转移。
3. **文献名称**：*THAP12 modulates epigenetic regulation by interacting with histone methyltransferase complexes*
**作者**：Gupta R, et al.
**摘要**：利用THAP12抗体进行染色质免疫沉淀测序(ChIP-seq)，发现THAP12与组蛋白甲基转移酶复合物结合，调控靶基因的染色质修饰及转录活性。
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注：以上文献信息为模拟示例，实际研究需通过PubMed、Google Scholar等平台检索关键词“THAP12 antibody”或“THAP12 function”获取最新数据。
The THAP12 antibody is a tool used to study the THAP domain-containing protein 12 (THAP12), a member of the THAP family of zinc-coordinating DNA-binding proteins. THAP12. also known as Thanatos-associated protein 12. is involved in transcriptional regulation and chromatin modification. It contains a conserved THAP domain at its N-terminus, which mediates sequence-specific DNA binding and protein-protein interactions. THAP12 is implicated in diverse cellular processes, including cell cycle control, apoptosis, and epigenetic regulation. Studies suggest it may function as part of multi-protein complexes, potentially interacting with chromatin remodelers or transcription factors to modulate gene expression.
Antibodies targeting THAP12 are primarily used in research to investigate its expression patterns, subcellular localization, and molecular interactions. They enable techniques such as Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP). THAP12's role in diseases remains under exploration, though aberrant expression has been linked to certain cancers and neurological disorders. For example, reduced THAP12 levels correlate with poor prognosis in glioblastoma, while its dysregulation may influence tumorigenesis via pathways like Wnt/β-catenin signaling. The antibody's specificity and validation (e.g., knockout validation) are critical to ensure accurate detection, given potential cross-reactivity with other THAP family members. Overall, THAP12 antibodies serve as essential reagents for unraveling the protein's functional and pathological significance.
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