| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | MTf; MFI2; MTF1; CD228; MAP97 |
| WB Predicted band size | 80 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human MELTF |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于MELTF抗体的3篇参考文献示例(注：以下内容为模拟虚构，仅供参考格式)：
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1. **文献名称**：*Melanotransferrin (MELTF) as a Potential Biomarker in Colorectal Cancer: Immunohistochemical Analysis*
**作者**：Smith J, et al.
**摘要**：本研究通过免疫组化(IHC)分析了MELTF蛋白在结直肠癌组织中的表达，使用特异性MELTF抗体发现其高表达与肿瘤转移和不良预后显著相关，提示MELTF可能作为治疗靶点。
2. **文献名称**：*Development and Validation of a Novel Monoclonal Antibody for MELTF Detection in Serum*
**作者**：Li X, et al.
**摘要**：作者开发了一种新型抗MELTF单克隆抗体，并通过ELISA和Western blot验证其灵敏度和特异性，证实该抗体可用于血清样本中MELTF的定量检测，为癌症早期诊断提供工具。
3. **文献名称**：*MELTF Regulates Iron Homeostasis in Neurodegenerative Diseases: Insights from Knockout Mice Models*
**作者**：Garcia R, et al.
**摘要**：利用MELTF抗体对基因敲除小鼠脑组织进行蛋白定位分析，发现MELTF通过调控脑内铁代谢影响神经退行性疾病进程，为阿尔茨海默病机制研究提供新方向。
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如需真实文献，建议通过PubMed或Google Scholar以关键词“MELTF antibody”或“melanotransferrin”检索近年研究。
The MELTF gene encodes melanotransferrin (MTf), a glycoprotein belonging to the transferrin family, initially identified in melanoma cells. Unlike its homolog transferrin, MTf binds iron but does not directly mediate cellular iron uptake via classical receptor pathways. Instead, it is implicated in diverse biological processes, including iron homeostasis, cell proliferation, and angiogenesis. MTf is anchored to the cell membrane via a glycosylphosphatidylinositol (GPI) linkage but can also exist in soluble forms, detected in blood and other fluids.
MELTF antibodies are tools used to study MTf's roles in physiology and disease. Research highlights MTf overexpression in cancers (e.g., melanoma, breast, and colorectal), where it may promote tumor growth and metastasis, making it a potential therapeutic target or biomarker. Antibodies against MTf enable detection of its expression in tissues or serum, aiding in cancer diagnosis, prognosis, and mechanistic studies. Additionally, MTf’s involvement in Alzheimer’s disease (via interactions with amyloid-beta) and iron metabolism disorders has spurred interest in therapeutic antibody development.
Despite progress, MTf's precise molecular mechanisms remain unclear, necessitating further research. MELTF antibodies thus serve as critical reagents to unravel its dual roles in health and disease.
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