Rabbit Polyclonal PSPC1 Antibody

The PSPC1 (Paraspeckle Component 1) antibody is a tool used to study the PSPC1 protein, a key component of paraspeckles—dynamic subnuclear bodies involved in RNA metabolism and gene regulation. PSPC1. first identified in 2005. interacts with the long non-coding RNA NEAT1 to maintain paraspeckle structure and function. It acts as a scaffolding protein, mediating RNA-protein interactions and regulating processes like transcriptional repression, RNA splicing, and stress response. PSPC1 is implicated in cellular stress adaptation, viral infection responses, and cancer progression, where its dysregulation correlates with tumor metastasis and therapy resistance. Researchers use PSPC1 antibodies in techniques such as Western blotting, immunofluorescence, and immunoprecipitation to investigate its expression, localization, and molecular interactions. These studies help elucidate its role in diseases and potential as a therapeutic target. The antibody’s specificity is critical for distinguishing PSPC1 from other paraspeckle proteins (e.g., NONO, SFPQ) and validating its involvement in disease mechanisms or experimental models.