| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | OAS |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human SMOC1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于SMOC1抗体的3篇参考文献示例(内容为模拟，供参考)：
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1. **文献名称**：*SMOC1 is essential for ocular and limb development in humans and mice*
**作者**：Okada et al.
**摘要**：本研究通过基因敲除小鼠模型和人类遗传学分析，发现SMOC1在眼部和四肢发育中的关键作用。作者利用特异性SMOC1抗体进行免疫组化，证实该蛋白在胚胎发育过程中高表达于晶状体和软骨组织，突变导致严重发育异常。
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2. **文献名称**：*SMOC1 as a novel biomarker in colorectal cancer progression*
**作者**：Zhang et al.
**摘要**：研究通过免疫印迹(Western blot)和免疫荧光技术，使用抗SMOC1抗体检测其在结直肠癌组织中的表达。结果显示，SMOC1在转移性肿瘤中显著上调，提示其可能通过调控细胞外基质促进癌细胞侵袭。
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3. **文献名称**：*Development of a monoclonal antibody against human SMOC1 and its diagnostic application*
**作者**：Müller et al.
**摘要**：本文报道了一种新型SMOC1单克隆抗体的开发与验证。通过ELISA和流式细胞术验证其特异性，并成功应用于眼科疾病(如先天性小眼球症)患者的组织样本检测，证明该抗体在临床诊断中的潜在价值。
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注：以上文献为示例，实际引用需根据具体研究通过PubMed或Google Scholar检索(关键词如“SMOC1 antibody”、“SMOC1 immunohistochemistry”)。
SMOC1 (SPARC-related modular calcium-binding protein 1) is a secreted glycoprotein belonging to the SPARC family, which regulates extracellular matrix (ECM) organization and cellular interactions. It contains characteristic domains, including a follistatin-like domain and two calcium-binding EC domains, enabling its role in modulating cell adhesion, proliferation, and tissue morphogenesis. SMOC1 is implicated in embryonic development, particularly in limb formation, neural tube closure, and eye development, through interactions with growth factors like BMP and Wnt. Dysregulation of SMOC1 has been linked to pathologies such as cancer, fibrosis, and ophthalmic disorders (e.g., age-related macular degeneration).
SMOC1 antibodies are essential tools for detecting and analyzing SMOC1 expression and function in research. They are widely used in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to study SMOC1 localization in tissues or cultured cells. Specific antibodies targeting distinct epitopes help elucidate SMOC1’s dual roles in promoting or inhibiting tumor progression, depending on context. Additionally, these antibodies aid in exploring SMOC1’s involvement in ECM remodeling, angiogenesis, and developmental pathways, offering insights into therapeutic targeting for diseases linked to SMOC1 dysregulation. Commercial SMOC1 antibodies are typically validated for cross-reactivity and specificity across human, mouse, and rat models.
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