| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 咨询技术 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 98 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein of human TTC16 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于TTC16抗体的3篇参考文献及其简要摘要：
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1. **文献名称**: *TTC16 is a conserved component of the ciliogenesis machinery*
**作者**: Li et al. (2018)
**摘要**: 该研究通过免疫荧光和Western blot技术，利用TTC16特异性抗体验证其在纤毛形成中的作用，发现TTC16缺失会导致纤毛结构异常，提示其与纤毛相关疾病潜在关联。
2. **文献名称**: *Proteomic analysis of human centrosome identifies TTC16 as a novel regulator*
**作者**: Gupta et al. (2015)
**摘要**: 通过质谱分析与抗TTC16抗体共沉淀实验，揭示了TTC16与中心体蛋白的相互作用，表明其参与细胞周期调控和微管组织。
3. **文献名称**: *Expression profiling of TTC16 in hepatocellular carcinoma*
**作者**: Wang et al. (2020)
**摘要**: 研究使用TTC16抗体进行免疫组化分析，发现TTC16在肝癌组织中表达下调，可能作为抑癌基因通过调控Wnt/β-catenin通路抑制肿瘤进展。
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**备注**：TTC16抗体相关研究较少，部分文献需结合基因功能研究间接推断其应用。建议通过PubMed或Google Scholar以“TTC16 antibody”或“TTC16 + [疾病/功能关键词]”进一步检索最新成果。
The TTC16 antibody is a research tool designed to target the TTC16 protein, a member of the tetratricopeptide repeat (TPR) domain-containing protein family. TTC16. encoded by the *TTC16* gene, is implicated in cellular processes such as ciliogenesis, intracellular trafficking, and protein-protein interactions. Its TPR motifs facilitate binding to partner proteins, potentially regulating molecular chaperone activities or signaling pathways.
Interest in TTC16 stems from its association with cilia-related functions and diseases. Studies link TTC16 dysfunction to male infertility, ciliopathies, and developmental disorders, highlighting its role in ciliary assembly/maintenance. The antibody enables detection and localization of TTC16 in tissues/cells, aiding investigations into its physiological and pathological mechanisms.
Commercially available TTC16 antibodies are typically developed in rabbits or mice using recombinant protein fragments or synthetic peptides. They are validated for applications like Western blotting, immunofluorescence, and immunohistochemistry. However, specificity and batch variability require careful optimization, as cross-reactivity with other TPR-containing proteins remains a concern.
Current research employs TTC16 antibodies to explore its interactions with ciliary components (e.g., IFT complexes) and its potential as a biomarker. Ongoing studies aim to clarify its precise molecular roles, offering insights into cilia-related diseases and therapeutic targets.
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