| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | RanBP11 |
| WB Predicted band size | 113 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse |
| Immunogen | Fusion protein of human IPO11 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3篇可能与IPO11抗体相关的参考文献示例(注：文献为假设性概括，实际引用需核实)：
1. **文献名称**: *Importin-11 regulates glioma cell proliferation via nuclear transport of PTEN*
**作者**: Zhang, Y. et al.
**摘要**: 研究利用IPO11抗体通过免疫沉淀和Western blot分析，揭示IPO11通过介导PTEN的核质转运影响胶质瘤细胞增殖的机制。
2. **文献名称**: *Structural insights into the nuclear import receptor IPO11-cargo recognition*
**作者**: Pumroy, R.A. & Cingolani, G.
**摘要**: 通过冷冻电镜和IPO11抗体的表位定位，解析了IPO11与肿瘤抑制蛋白RB1的结合结构，阐明其核转运特异性。
3. **文献名称**: *IPO11 expression correlates with poor prognosis in colorectal cancer*
**作者**: Wang, L. et al.
**摘要**: 使用IPO11抗体进行免疫组化分析，发现IPO11在结直肠癌中高表达，且与患者生存率负相关，提示其作为预后标志物的潜力。
**建议**：可通过PubMed或Google Scholar以“IPO11 antibody”或“Importin-11 antibody”为关键词检索最新文献，重点关注抗体在疾病模型或分子机制研究中的应用。
The IPO11 antibody targets Importin 11 (IPO11), a nuclear transport receptor belonging to the importin β family. IPO11 facilitates the transport of proteins from the cytoplasm to the nucleus by forming heterodimers with importin α adaptors, recognizing cargo proteins containing classical nuclear localization signals (NLS). It plays a critical role in maintaining cellular processes such as gene expression regulation, cell cycle progression, and genome stability. IPO11 has been implicated in cancer research due to its interaction with oncogenic proteins like β-catenin, influencing Wnt signaling and tumor progression. Studies suggest IPO11 overexpression in certain cancers (e.g., colorectal, hepatocellular carcinoma) correlates with poor prognosis, highlighting its potential as a therapeutic target or biomarker.
The IPO11 antibody is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to detect IPO11 expression and localization in cells or tissues. Researchers utilize it to explore IPO11's functional roles in nuclear transport mechanisms, disease pathways, and its regulatory effects on ubiquitination processes. Antibody specificity is validated through knockdown/knockout controls, ensuring reliable detection of the ~110 kDa protein. Commercial antibodies are typically raised in rabbits or mice, with reactivity across human, mouse, and rat samples. Ongoing studies aim to clarify IPO11's diverse cargo proteins and its broader implications in cellular homeostasis and disease.
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