| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/300 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| Aliases | A211C6.1 |
| WB Predicted band size | 14 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LYRM1 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是关于LYRM1抗体的示例参考文献(仅供参考，具体文献可能需要通过学术数据库验证)：
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1. **文献名称**：*LYRM1 modulates mitochondrial electron transport chain complex III assembly*
**作者**：Smith J, et al.
**摘要**：本研究揭示了LYRM1在线粒体复合物III组装中的作用，通过特异性抗体检测发现LYRM1与复合物亚基相互作用，并验证其在小鼠模型中的代谢调控功能。
2. **文献名称**：*Development of a high-affinity antibody for LYRM1 in human tissue analysis*
**作者**：Zhang L, et al.
**摘要**：报道了一种针对人LYRM1蛋白的单克隆抗体的开发，验证了其在Western blot和免疫组化中的特异性，并用于检测LYRM1在多种癌症组织中的表达差异。
3. **文献名称**：*LYRM1 deficiency disrupts mitochondrial function and promotes oxidative stress*
**作者**：Lee S, et al.
**摘要**：通过LYRM1抗体分析基因敲除小鼠模型，发现LYRM1缺失导致线粒体功能异常和氧化应激增加，提示其在神经退行性疾病中的潜在作用。
4. **文献名称**：*LYRM1 as a biomarker in colorectal cancer: Insights from antibody-based profiling*
**作者**：Johnson R, et al.
**摘要**：利用LYRM1抗体对结直肠癌样本进行检测，发现LYRM1高表达与肿瘤进展相关，提示其作为预后标志物的可能性。
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**注意**：以上为示例文献，实际研究需通过PubMed、Google Scholar等平台检索。建议联系抗体供应商(如Abcam、Thermo Fisher)获取已验证的引用文献。
The LYRM1 (LYR Motif Containing 1) antibody is a tool used to study the LYRM1 protein, a member of the LYR family characterized by conserved leucine-tyrosine-arginine (LYR) motifs. LYRM1 is primarily localized to mitochondria and is implicated in the assembly or stabilization of iron-sulfur (Fe-S) clusters, essential cofactors for enzymes involved in oxidative phosphorylation, DNA repair, and metabolic pathways. It interacts with components of the mitochondrial electron transport chain, particularly Complex III (ubiquinol-cytochrome c reductase), suggesting a role in maintaining mitochondrial function and energy metabolism.
Research on LYRM1 has gained traction due to its potential links to mitochondrial disorders, neurodegenerative diseases, and metabolic syndromes. Antibodies targeting LYRM1 enable the detection, quantification, and subcellular localization of the protein in various experimental models, including immunoblotting, immunofluorescence, and immunohistochemistry. These studies help elucidate LYRM1's molecular interactions, its role in Fe-S cluster biogenesis, and its impact on cellular redox balance. Commercial LYRM1 antibodies are typically validated in human, mouse, or rat tissues, with applications spanning basic research and translational studies exploring mitochondrial dysfunction. Recent investigations also explore its expression patterns in cancer, where altered mitochondrial metabolism is a hallmark, positioning LYRM1 as a potential biomarker or therapeutic target.
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