| WB | 咨询技术 | Human,Mouse,Rat |
| IF | 咨询技术 | Human,Mouse,Rat |
| IHC | 1/50-1/200 | Human,Mouse,Rat |
| ICC | 技术咨询 | Human,Mouse,Rat |
| FCM | 咨询技术 | Human,Mouse,Rat |
| Elisa | 1/5000-1/10000 | Human,Mouse,Rat |
| WB Predicted band size | 12 kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human, Mouse, Rat |
| Immunogen | Fusion protein of human LBH |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
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以下是3-4条关于LBH抗体的参考文献示例(注：以下内容为模拟示例，实际文献需通过学术数据库查询)：
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1. **文献名称**：*LBH Antibody Validation in Triple-Negative Breast Cancer Prognosis*
**作者**：Bakker, E. R., & Stewart, L. M.
**摘要**：本研究验证了LBH抗体在乳腺癌组织中的特异性，发现LBH蛋白高表达与三阴性乳腺癌患者预后不良相关。通过免疫组化证实其与肿瘤增殖标志物(如Ki-67)的正相关性。
2. **文献名称**：*Role of LBH in Neural Crest Development: Insights from Antibody-Based Localization*
**作者**：Liu, Y., et al.
**摘要**：利用LBH特异性抗体在小鼠胚胎模型中定位LBH蛋白，发现其在神经嵴细胞迁移中高表达，并通过敲除实验证明LBH对颅面发育的关键调控作用。
3. **文献名称**：*LBH Interacts with Wnt Signaling Components: Co-IP Studies Using Novel Antibodies*
**作者**：Schmidt, T., et al.
**摘要**：开发了一种高特异性兔源LBH多克隆抗体，并通过免疫共沉淀(Co-IP)技术揭示LBH与Wnt通路蛋白(如β-catenin)的相互作用，提示其在结直肠癌中的潜在机制。
4. **文献名称**：*Review: Applications and Challenges of LBH Antibodies in Cancer Research*
**作者**：Johnson, R. W.
**摘要**：综述了LBH抗体在肿瘤研究中的应用，包括诊断标志物筛选和机制研究，同时讨论了不同抗体克隆(如Abcam #12345 vs. CST #6789)的交叉反应性和验证标准。
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**注意**：以上为模拟文献，如需真实数据，建议通过PubMed、Google Scholar或Web of Science检索关键词(如“LBH antibody”、“LBH protein function”)，并筛选近年高被引研究。
LBH (Limb-Bud and Heart) is a conserved vertebrate protein initially identified for its role in embryonic development, particularly in limb formation and heart morphogenesis. It functions as a transcriptional co-regulator, interacting with key signaling pathways like Wnt/β-catenin and BMP to modulate gene expression. LBH is highly expressed during embryogenesis but shows restricted tissue distribution in adults, primarily in the brain, heart, and kidneys.
In recent years, LBH has gained attention in cancer research due to its dysregulation in malignancies such as breast, ovarian, and colorectal cancers. It exhibits dual roles depending on context: acting as an oncogene in certain cancers (promoting proliferation and metastasis) or a tumor suppressor in others. This complexity has driven interest in developing LBH-targeted antibodies for research and therapeutic purposes.
LBH antibodies are primarily used to detect and quantify LBH expression in tissues or cell lines via techniques like Western blot, immunohistochemistry, or flow cytometry. They help elucidate LBH's functional mechanisms, interactions, and clinical associations. Some studies also explore LBH antibodies as potential diagnostic biomarkers or therapeutic agents, though clinical applications remain experimental. Challenges include optimizing antibody specificity due to LBH's small size (~12 kDa) and structural homology with other proteins.
Overall, LBH antibodies are critical tools for advancing understanding of LBH's multifaceted roles in development and disease.
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